Ginkgolide A Prevents the Amyloid-β-Induced Depolarization of Cortical Neurons

Li Chen Kuo, Yan Qing Song, Chien An Yao, Irene H. Cheng, Chiang Ting Chien, Guan Chiun Lee, Wen Chin Yang, Yenshou Lin*

*此作品的通信作者

研究成果: 雜誌貢獻期刊論文同行評審

8 引文 斯高帕斯(Scopus)

摘要

Utilizing the N-methyl-d-aspartate (NMDA) receptor antagonist as a strategy, memantine is the only agent available for clinically treating mild to severe Alzheimer's disease (AD). Our aim was to develop novel similar herb-based drugs. Using a screening platform, ginkgolide A (GA), a pure compound extracted from Ginkgo biloba, was found to attenuate amyloid β (Aβ)-induced abnormal depolarization in mouse primary cortical neurons. Using receptor agonists, it was determined that GA inhibits both NMDA receptors and α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors. Furthermore, the Aβ-induced increase in c-Jun N-terminal kinase phosphorylation in neurons was prevented by GA. Body weight, glutamate oxaloacetate transaminase, glutamic-pyruvic transaminase, liver histology, and kidney histology were similar when the wild-type/AD animal model mice with and without GA treatment were compared. This pure compound improves the memory of wild-type mice. Our findings indicate that GA has great potential clinically for the treatment of AD because it might target NMDA receptors just like memantine.

原文英語
頁(從 - 到)81-89
頁數9
期刊Journal of Agricultural and Food Chemistry
67
發行號1
DOIs
出版狀態已發佈 - 2019 一月 9

ASJC Scopus subject areas

  • 化學 (全部)
  • 農業與生物科學 (全部)

指紋

深入研究「Ginkgolide A Prevents the Amyloid-β-Induced Depolarization of Cortical Neurons」主題。共同形成了獨特的指紋。

引用此