Genomic Consequences of Long-Term Population Decline in Brown Eared Pheasant

Pengcheng Wang, John T. Burley, Yang Liu, Jiang Chang, De Chen, Qi Lu, Shou Hsien Li, Xuming Zhou, Scott Edwards, Zhengwang Zhang*

*此作品的通信作者

研究成果: 雜誌貢獻期刊論文同行評審

摘要

Population genetic theory and empirical evidence indicate that deleterious alleles can be purged in small populations. However, this viewpoint remains controversial. It is unclear whether natural selection is powerful enough to purge deleterious mutations when wild populations continue to decline. Pheasants are terrestrial birds facing a long-term risk of extinction as a result of anthropogenic perturbations and exploitation. Nevertheless, there are scant genomics resources available for conservation management and planning. Here, we analyzed comparative population genomic data for the three extant isolated populations of Brown eared pheasant (Crossoptilon mantchuricum) in China. We showed that C. mantchuricum has low genome-wide diversity and a contracting effective population size because of persistent declines over the past 100,000 years. We compared genome-wide variation in C. mantchuricum with that of its closely related sister species, the Blue eared pheasant (C. auritum) for which the conservation concern is low. There were detrimental genetic consequences across all C. mantchuricum genomes including extended runs of homozygous sequences, slow rates of linkage disequilibrium decay, excessive loss-of-function mutations, and loss of adaptive genetic diversity at the major histocompatibility complex region. To the best of our knowledge, this study is the first to perform a comprehensive conservation genomic analysis on this threatened pheasant species. Moreover, we demonstrated that natural selection may not suffice to purge deleterious mutations in wild populations undergoing long-term decline. The findings of this study could facilitate conservation planning for threatened species and help recover their population size.

原文英語
頁(從 - 到)263-273
頁數11
期刊Molecular Biology and Evolution
38
發行號1
DOIs
出版狀態已發佈 - 2021 一月 1

ASJC Scopus subject areas

  • 生態學、進化論、行為學與系統學
  • 分子生物學
  • 遺傳學

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