Genetic analysis of HLA-DRA region variation in Taiwanese Parkinson's disease

Han Lin Chiang; Guey Jen Lee-Chen; Chiung Mei Chen; Yi Chun Chen; Chei Mei Lee; Ming Hui Liao; Yih Ru Wu

doi:10.1016/j.parkreldis.2011.12.014

Genetic analysis of HLA-DRA region variation in Taiwanese Parkinson's disease

Han Lin Chiang
, Guey Jen Lee-Chen
, Chiung Mei Chen
, Yi Chun Chen
, Chei Mei Lee
, Ming Hui Liao
, Yih Ru Wu^*

^*此作品的通信作者

生命科學系

研究成果: 雜誌貢獻 › 期刊論文 › 同行評審

17 引文斯高帕斯（Scopus）

摘要

Parkinson's disease (PD) is a neurodegenerative disorder comprising both motor and cognitive disability. The pathogenesis of the disease is still unclear; however, neuroinflammation seemed to play a role. A recent genome-wide association study (GWAS) reported an association between HLA-DRA rs3129882 and the development of PD in Caucasian populations. In this study, we observe no association between this single nucleotide polymorphism and PD in a Taiwanese population. The possible reasons include different ethnicity with genomic differences and environmental factors in different geographical regions.

原文	英語
頁（從 - 到）	391-393
頁數	3
期刊	Parkinsonism and Related Disorders
卷	18
發行號	4
DOIs	https://doi.org/10.1016/j.parkreldis.2011.12.014
出版狀態	已發佈 - 2012 5月

ASJC Scopus subject areas

神經內科
老年病學和老年學
神經病學（臨床）

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10.1016/j.parkreldis.2011.12.014

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title = "Genetic analysis of HLA-DRA region variation in Taiwanese Parkinson's disease",

abstract = "Parkinson's disease (PD) is a neurodegenerative disorder comprising both motor and cognitive disability. The pathogenesis of the disease is still unclear; however, neuroinflammation seemed to play a role. A recent genome-wide association study (GWAS) reported an association between HLA-DRA rs3129882 and the development of PD in Caucasian populations. In this study, we observe no association between this single nucleotide polymorphism and PD in a Taiwanese population. The possible reasons include different ethnicity with genomic differences and environmental factors in different geographical regions.",

keywords = "Disease association, HLA, Parkinson's disease, Polymorphism",

author = "Chiang, \{Han Lin\} and Lee-Chen, \{Guey Jen\} and Chen, \{Chiung Mei\} and Chen, \{Yi Chun\} and Lee, \{Chei Mei\} and Liao, \{Ming Hui\} and Wu, \{Yih Ru\}",

note = "Funding Information: This work was supported by grant NSC98-2628-B-182A-001-MY3 from the National Science Council, Executive Yuan and grant CMRPG391181 and CMRPG3A0131 from Chang–Gung Memorial Hospital . We also thank the patients and controls for participating in this study. All authors have no conflict of interest to declare. ",

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doi = "10.1016/j.parkreldis.2011.12.014",

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AU - Chiang, Han Lin

AU - Lee-Chen, Guey Jen

AU - Chen, Chiung Mei

AU - Chen, Yi Chun

AU - Lee, Chei Mei

AU - Liao, Ming Hui

AU - Wu, Yih Ru

N1 - Funding Information: This work was supported by grant NSC98-2628-B-182A-001-MY3 from the National Science Council, Executive Yuan and grant CMRPG391181 and CMRPG3A0131 from Chang–Gung Memorial Hospital . We also thank the patients and controls for participating in this study. All authors have no conflict of interest to declare.

PY - 2012/5

Y1 - 2012/5

N2 - Parkinson's disease (PD) is a neurodegenerative disorder comprising both motor and cognitive disability. The pathogenesis of the disease is still unclear; however, neuroinflammation seemed to play a role. A recent genome-wide association study (GWAS) reported an association between HLA-DRA rs3129882 and the development of PD in Caucasian populations. In this study, we observe no association between this single nucleotide polymorphism and PD in a Taiwanese population. The possible reasons include different ethnicity with genomic differences and environmental factors in different geographical regions.

AB - Parkinson's disease (PD) is a neurodegenerative disorder comprising both motor and cognitive disability. The pathogenesis of the disease is still unclear; however, neuroinflammation seemed to play a role. A recent genome-wide association study (GWAS) reported an association between HLA-DRA rs3129882 and the development of PD in Caucasian populations. In this study, we observe no association between this single nucleotide polymorphism and PD in a Taiwanese population. The possible reasons include different ethnicity with genomic differences and environmental factors in different geographical regions.

KW - Disease association

KW - HLA

KW - Parkinson's disease

KW - Polymorphism

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DO - 10.1016/j.parkreldis.2011.12.014

M3 - Article

C2 - 22243834

AN - SCOPUS:84862811884

SN - 1353-8020

VL - 18

SP - 391

EP - 393

JO - Parkinsonism and Related Disorders

JF - Parkinsonism and Related Disorders

IS - 4

ER -

Genetic analysis of HLA-DRA region variation in Taiwanese Parkinson's disease

摘要

ASJC Scopus subject areas

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