@article{59f288b15afa4bfeafedaa37eb1b724b,
title = "Genetic analysis of HLA-DRA region variation in Taiwanese Parkinson's disease",
abstract = "Parkinson's disease (PD) is a neurodegenerative disorder comprising both motor and cognitive disability. The pathogenesis of the disease is still unclear; however, neuroinflammation seemed to play a role. A recent genome-wide association study (GWAS) reported an association between HLA-DRA rs3129882 and the development of PD in Caucasian populations. In this study, we observe no association between this single nucleotide polymorphism and PD in a Taiwanese population. The possible reasons include different ethnicity with genomic differences and environmental factors in different geographical regions.",
keywords = "Disease association, HLA, Parkinson's disease, Polymorphism",
author = "Chiang, {Han Lin} and Lee-Chen, {Guey Jen} and Chen, {Chiung Mei} and Chen, {Yi Chun} and Lee, {Chei Mei} and Liao, {Ming Hui} and Wu, {Yih Ru}",
note = "Funding Information: This work was supported by grant NSC98-2628-B-182A-001-MY3 from the National Science Council, Executive Yuan and grant CMRPG391181 and CMRPG3A0131 from Chang–Gung Memorial Hospital . We also thank the patients and controls for participating in this study. All authors have no conflict of interest to declare. ",
year = "2012",
month = may,
doi = "10.1016/j.parkreldis.2011.12.014",
language = "English",
volume = "18",
pages = "391--393",
journal = "Parkinsonism and Related Disorders",
issn = "1353-8020",
publisher = "Elsevier BV",
number = "4",
}