GABAergic inhibition contributes to pulse repetition rate-dependent frequency selectivity in the inferior colliculus of the big brown bat, Eptesicus fuscus

Philip H.S. Jen; Chung Hsin Wu; Rui Hong Luan; Xiaoming Zhou

doi:10.1016/S0006-8993(02)03056-1

GABAergic inhibition contributes to pulse repetition rate-dependent frequency selectivity in the inferior colliculus of the big brown bat, Eptesicus fuscus

Philip H.S. Jen, Chung Hsin Wu, Rui Hong Luan, Xiaoming Zhou

研究成果: 雜誌貢獻 › 期刊論文 › 同行評審

22 引文斯高帕斯（Scopus）

摘要

This study examined the effect of bicuculline application on sharpness of frequency tuning curves (FTCs) of bat inferior collicular neurons plotted under three different pulse repetition rates (PRRs) of 10, 30 and 90 pulses per second. The sharpness of FTCs of collicular neurons, which was expressed in Q_n (Q₁₀, Q₂₀, Q₃₀) and bandwidths (90, 75 and 50% of the maximal response at the best frequency), improved with increasing PRR. However, this PRR-dependent frequency selectivity of collicular neurons was abolished during bicuculline application. This observation suggests that GABAergic inhibition contributes more effectively to sharpening of FTCs at higher than at lower PRRs.

原文	英語
頁（從 - 到）	159-164
頁數	6
期刊	Brain Research
卷	948
發行號	1-2
DOIs	https://doi.org/10.1016/S0006-8993(02)03056-1
出版狀態	已發佈 - 2002 9月 6
對外發佈	是

ASJC Scopus subject areas

神經科學 (全部)
分子生物學
神經病學（臨床）
發展生物學

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10.1016/S0006-8993(02)03056-1

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title = "GABAergic inhibition contributes to pulse repetition rate-dependent frequency selectivity in the inferior colliculus of the big brown bat, Eptesicus fuscus",

abstract = "This study examined the effect of bicuculline application on sharpness of frequency tuning curves (FTCs) of bat inferior collicular neurons plotted under three different pulse repetition rates (PRRs) of 10, 30 and 90 pulses per second. The sharpness of FTCs of collicular neurons, which was expressed in Qn (Q10, Q20, Q30) and bandwidths (90, 75 and 50% of the maximal response at the best frequency), improved with increasing PRR. However, this PRR-dependent frequency selectivity of collicular neurons was abolished during bicuculline application. This observation suggests that GABAergic inhibition contributes more effectively to sharpening of FTCs at higher than at lower PRRs.",

keywords = "Bat, Frequency selectivity, Inferior colliculus, Pulse repetition rate",

author = "Jen, {Philip H.S.} and Wu, {Chung Hsin} and Luan, {Rui Hong} and Xiaoming Zhou",

note = "Funding Information: This work was supported by a research grant from the National Science Foundation (NSF IBN 9907610) and matching funds from the College of Arts and Sciences and the Division of Biological Sciences of the University of Missouri.",

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AU - Jen, Philip H.S.

AU - Wu, Chung Hsin

AU - Luan, Rui Hong

AU - Zhou, Xiaoming

N1 - Funding Information: This work was supported by a research grant from the National Science Foundation (NSF IBN 9907610) and matching funds from the College of Arts and Sciences and the Division of Biological Sciences of the University of Missouri.

PY - 2002/9/6

Y1 - 2002/9/6

N2 - This study examined the effect of bicuculline application on sharpness of frequency tuning curves (FTCs) of bat inferior collicular neurons plotted under three different pulse repetition rates (PRRs) of 10, 30 and 90 pulses per second. The sharpness of FTCs of collicular neurons, which was expressed in Qn (Q10, Q20, Q30) and bandwidths (90, 75 and 50% of the maximal response at the best frequency), improved with increasing PRR. However, this PRR-dependent frequency selectivity of collicular neurons was abolished during bicuculline application. This observation suggests that GABAergic inhibition contributes more effectively to sharpening of FTCs at higher than at lower PRRs.

AB - This study examined the effect of bicuculline application on sharpness of frequency tuning curves (FTCs) of bat inferior collicular neurons plotted under three different pulse repetition rates (PRRs) of 10, 30 and 90 pulses per second. The sharpness of FTCs of collicular neurons, which was expressed in Qn (Q10, Q20, Q30) and bandwidths (90, 75 and 50% of the maximal response at the best frequency), improved with increasing PRR. However, this PRR-dependent frequency selectivity of collicular neurons was abolished during bicuculline application. This observation suggests that GABAergic inhibition contributes more effectively to sharpening of FTCs at higher than at lower PRRs.

KW - Bat

KW - Frequency selectivity

KW - Inferior colliculus

KW - Pulse repetition rate

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GABAergic inhibition contributes to pulse repetition rate-dependent frequency selectivity in the inferior colliculus of the big brown bat, Eptesicus fuscus

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