Formal total synthesis of FK506. Concise construction of the C(10)-C(34) segment via an effective coupling tactic

Amos B. Smith, Kwunmin Chen, Darius J. Robinson, Leif M. Laakso, Karl J. Hale

研究成果: 雜誌貢獻文章同行評審

33 引文 斯高帕斯(Scopus)

摘要

A formal total synthesis of the potent immunosuppressant FK506 (1) has been achieved via a concise construction of the Merck advanced intermediate (-)-2. Key features of the successful strategy include stereocontrolled σ-bond installation of the trisubstituted olefin moieties and an efficient coupling of the C(24)-C(34) dithiane (-)-10 with the C(10)-C(23) α-silyloxy primary iodide (-)-9.

原文英語
頁(從 - 到)4271-4274
頁數4
期刊Tetrahedron Letters
35
發行號25
DOIs
出版狀態已發佈 - 1994 六月 20

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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