Fast multipoint immobilization of lipase through chirall-proline on a MOF as a chiral bioreactor

Stephen Lirio, Yung Han Shih, Pamela Berilyn So, Li Hao Liu, Yun Ting Yen, Shuhei Furukawa*, Wan Ling Liu, Hsi Ya Huang, Chia Her Lin

*此作品的通信作者

研究成果: 雜誌貢獻期刊論文同行評審

1 引文 斯高帕斯(Scopus)

摘要

In this paper, we describe the facile preparation of a chiral catalyst by the combination of the amino acid,l-proline (Pro), and the enzyme, porcine pancreas lipase (PPL), immobilized on a microporous metal-organic framework (PPL-Pro@MOF). The multipoint immobilization of PPL onto the MOF is made possible with the aid of Pro, which also provided a chiral environment for enhanced enantioselectivity. The application of the microporous MOF is pivotal in maintaining the catalytic activity of PPL, wherein it prevented the leaching of Pro during the catalytic reaction, leading to the enhanced activity of PPL. The prepared biocatalyst was applied in asymmetric carbon-carbon bond formation, demonstrating the potential of this simple approach for chemical transformations.

原文英語
頁(從 - 到)1866-1873
頁數8
期刊Dalton Transactions
50
發行號5
DOIs
出版狀態已發佈 - 2021 二月 7

ASJC Scopus subject areas

  • 無機化學

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