Facile synthesis of 4-arylidene-5-imidazolinones as synthetic analogs of fluorescent protein chromophore

Cheng Yu Lee, Yun Chung Chen, Hao Chun Lin, Yuandong Jhong, Chih Wei Chang, Ching Hua Tsai, Chai Lin Kao, Tun Cheng Chien*

*此作品的通信作者

研究成果: 雜誌貢獻期刊論文同行評審

37 引文 斯高帕斯(Scopus)

摘要

A facile and effective synthesis for a wide variety of 4-arylidene-5- imidazolinone derivatives was developed. 4-Arylidene-5-oxazolinones were prepared by Erlenmeyer azlactone synthesis from N-acylglycines and arylaldehydes. The ring-opening reactions of the 4-arylidene-5-oxazolinones with primary amines afforded 2-acylamino-3-arylacrylamides in excellent yields. A new dehydrative cyclization of the 2-acylamino-3-arylacrylamides in pyridine under reflux furnished the corresponding 4-arylidene-5-imidazolinones in good yields.

原文英語
頁(從 - 到)5898-5907
頁數10
期刊Tetrahedron
68
發行號29
DOIs
出版狀態已發佈 - 2012 7月 22

ASJC Scopus subject areas

  • 生物化學
  • 藥物發現
  • 有機化學

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