@article{bb4eaccecfa945aab4ce113ac050ea1d,
title = "Facile synthesis of 4-arylidene-5-imidazolinones as synthetic analogs of fluorescent protein chromophore",
abstract = "A facile and effective synthesis for a wide variety of 4-arylidene-5- imidazolinone derivatives was developed. 4-Arylidene-5-oxazolinones were prepared by Erlenmeyer azlactone synthesis from N-acylglycines and arylaldehydes. The ring-opening reactions of the 4-arylidene-5-oxazolinones with primary amines afforded 2-acylamino-3-arylacrylamides in excellent yields. A new dehydrative cyclization of the 2-acylamino-3-arylacrylamides in pyridine under reflux furnished the corresponding 4-arylidene-5-imidazolinones in good yields.",
keywords = "Acrylamide, Fluorescent protein chromophore, GFP, Imidazolinone, Oxazolinone",
author = "Lee, {Cheng Yu} and Chen, {Yun Chung} and Lin, {Hao Chun} and Yuandong Jhong and Chang, {Chih Wei} and Tsai, {Ching Hua} and Kao, {Chai Lin} and Chien, {Tun Cheng}",
note = "Funding Information: This work was supported by Research Grants 99-2113-M-003-003 - and 99-2320-B-037-012-MY3 from the National Science Council, Taiwan , NTNU100-D-06 from National Taiwan Normal University and from Kaohsiung Medical University Research Foundation . We are grateful to the National Center for High-performance Computing of Taiwan for the electronic resources and facilities. ",
year = "2012",
month = jul,
day = "22",
doi = "10.1016/j.tet.2012.04.102",
language = "English",
volume = "68",
pages = "5898--5907",
journal = "Tetrahedron",
issn = "0040-4020",
publisher = "Elsevier Limited",
number = "29",
}