TY - JOUR
T1 - Extraction of drug-drug interaction using neural embedding
AU - Hou, Wen Juan
AU - Ceesay, Bamfa
N1 - Publisher Copyright:
© 2018 The Author(s).
PY - 2018/12/1
Y1 - 2018/12/1
N2 - Information on changes in a drug's effect when taken in combination with a second drug, known as drug-drug interaction (DDI), is relevant in the pharmaceutical industry. DDIs can delay, decrease, or enhance absorption of either drug and thus decrease or increase their action or cause adverse effects. Information Extraction (IE) can be of great benefit in allowing identification and extraction of relevant information on DDIs. We here propose an approach for the extraction of DDI from text using neural word embedding to train a machine learning system. Results show that our system is competitive against other systems for the task of extracting DDIs, and that significant improvements can be achieved by learning from word features and using a deep-learning approach. Our study demonstrates that machine learning techniques such as neural networks and deep learning methods can efficiently aid in IE from text. Our proposed approach is well suited to play a significant role in future research.
AB - Information on changes in a drug's effect when taken in combination with a second drug, known as drug-drug interaction (DDI), is relevant in the pharmaceutical industry. DDIs can delay, decrease, or enhance absorption of either drug and thus decrease or increase their action or cause adverse effects. Information Extraction (IE) can be of great benefit in allowing identification and extraction of relevant information on DDIs. We here propose an approach for the extraction of DDI from text using neural word embedding to train a machine learning system. Results show that our system is competitive against other systems for the task of extracting DDIs, and that significant improvements can be achieved by learning from word features and using a deep-learning approach. Our study demonstrates that machine learning techniques such as neural networks and deep learning methods can efficiently aid in IE from text. Our proposed approach is well suited to play a significant role in future research.
KW - Drug-drug interaction
KW - data abstraction
KW - long short term memory (LSTM)
KW - neural networks
KW - word embedding
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U2 - 10.1142/S0219720018400279
DO - 10.1142/S0219720018400279
M3 - Article
C2 - 30567477
AN - SCOPUS:85058846686
SN - 0219-7200
VL - 16
JO - Journal of Bioinformatics and Computational Biology
JF - Journal of Bioinformatics and Computational Biology
IS - 6
M1 - 18400279
ER -