Exo-10,10-diphenyl-2,10-camphanediol as a new chiral auxiliary in asymmetric reduction

C. J. Chen; Y. Y. Chu; Y. Y. Liao; Z. H. Tsai; C. C. Wang; K. Chen

doi:10.1016/S0040-4039(98)02548-9

Exo-10,10-diphenyl-2,10-camphanediol as a new chiral auxiliary in asymmetric reduction

C. J. Chen, Y. Y. Chu, Y. Y. Liao, Z. H. Tsai, C. C. Wang, K. Chen^*

^*此作品的通信作者

研究成果: 雜誌貢獻 › 期刊論文 › 同行評審

13 引文斯高帕斯（Scopus）

摘要

Stereoselective reduction of α-keto ester derived from exo-10,10- diphenyl-2,10-camphanediol with various hydrides proceeded with high diastereoselectivities (≥ 96% de) to afford the corresponding α-hydroxy ester with excellent yields. Change of reducing reagents and molar ratio modifications leading to dramatic changes in diastereofacial selectivity were examined. The auxiliary can be recovered from the asymmetric reaction products without loss of chirality.

原文	英語
頁（從 - 到）	1141-1144
頁數	4
期刊	Tetrahedron Letters
卷	40
發行號	6
DOIs	https://doi.org/10.1016/S0040-4039(98)02548-9
出版狀態	已發佈 - 1999 2月 5
對外發佈	是

ASJC Scopus subject areas

生物化學
藥物發現
有機化學

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10.1016/S0040-4039(98)02548-9

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author = "Chen, {C. J.} and Chu, {Y. Y.} and Liao, {Y. Y.} and Tsai, {Z. H.} and Wang, {C. C.} and K. Chen",

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AU - Chen, C. J.

AU - Chu, Y. Y.

AU - Liao, Y. Y.

AU - Tsai, Z. H.

AU - Wang, C. C.

AU - Chen, K.

PY - 1999/2/5

Y1 - 1999/2/5

N2 - Stereoselective reduction of α-keto ester derived from exo-10,10- diphenyl-2,10-camphanediol with various hydrides proceeded with high diastereoselectivities (≥ 96% de) to afford the corresponding α-hydroxy ester with excellent yields. Change of reducing reagents and molar ratio modifications leading to dramatic changes in diastereofacial selectivity were examined. The auxiliary can be recovered from the asymmetric reaction products without loss of chirality.

AB - Stereoselective reduction of α-keto ester derived from exo-10,10- diphenyl-2,10-camphanediol with various hydrides proceeded with high diastereoselectivities (≥ 96% de) to afford the corresponding α-hydroxy ester with excellent yields. Change of reducing reagents and molar ratio modifications leading to dramatic changes in diastereofacial selectivity were examined. The auxiliary can be recovered from the asymmetric reaction products without loss of chirality.

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JO - Tetrahedron Letters

JF - Tetrahedron Letters

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ER -

Exo-10,10-diphenyl-2,10-camphanediol as a new chiral auxiliary in asymmetric reduction

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