Exo-10,10-diphenyl-2,10-camphanediol as a new chiral auxiliary in asymmetric reduction

C. J. Chen, Y. Y. Chu, Y. Y. Liao, Z. H. Tsai, C. C. Wang, K. Chen*

*此作品的通信作者

研究成果: 雜誌貢獻期刊論文同行評審

13 引文 斯高帕斯(Scopus)

摘要

Stereoselective reduction of α-keto ester derived from exo-10,10- diphenyl-2,10-camphanediol with various hydrides proceeded with high diastereoselectivities (≥ 96% de) to afford the corresponding α-hydroxy ester with excellent yields. Change of reducing reagents and molar ratio modifications leading to dramatic changes in diastereofacial selectivity were examined. The auxiliary can be recovered from the asymmetric reaction products without loss of chirality.

原文英語
頁(從 - 到)1141-1144
頁數4
期刊Tetrahedron Letters
40
發行號6
DOIs
出版狀態已發佈 - 1999 二月 5

ASJC Scopus subject areas

  • 生物化學
  • 藥物發現
  • 有機化學

指紋

深入研究「Exo-10,10-diphenyl-2,10-camphanediol as a new chiral auxiliary in asymmetric reduction」主題。共同形成了獨特的指紋。

引用此