Evaluation of thermo responsive magnetic nano-particles for high-Tc SQUID bio application

S. Tanaka*, C. Toriyabe, Y. Torii, Y. Hatsukade, T. Eki, S. Katsura, N. Ohnishi, J. Wan, S. Yang, Y. Zhang


研究成果: 雜誌貢獻期刊論文同行評審

2 引文 斯高帕斯(Scopus)


Immunoassay or detection of biological molecules using a high sensitive SQUID and magnetic nano-particles as labeling has been recently proposed. In this method, mostly a few particles are labeled on an antibody or biological molecules. If it is possible to give much more magnetic particles to the antibody, sensitivity must notably increase. We propose the use of thermo responsive magnetic nano-particles, which can agglutinate and disperse by themselves associated with temperature. As a preliminary experiment, we investigated the properties of thermo responsive nano-particles made of Fe3O4. By detailed study on the particles using an analyzer for a distribution of particle's outer dimension in aqueous liquid, it was found that the dimension increased with temperature above 25°, and became 400 nm at 30.5°. Magnetic measurements of the particles at different conditions using high-Tc SQUID have been done. The results suggested that the particles must be dried by heat before magnetic measurement to enhance the signal from the particles.

頁(從 - 到)1029-1033
期刊Physica C: Superconductivity and its applications
出版狀態已發佈 - 2007 10月 1

ASJC Scopus subject areas

  • 電子、光磁材料
  • 凝聚態物理學
  • 能源工程與電力技術
  • 電氣與電子工程


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