This study proposes an adaptive differential evolution (ADE)-based variable bias current control strategy to improve the energy efficiency of an active magnetic bearing (AMB) system. In the AMB system, the drive current is composed of a control current and a superimposed bias current in which the former is controlled by an external controller used to regulate the rotor position while the latter is set as a pre-designed constant used to improve the linearity and dynamic performance. Generally, the bias current causes power loss even if no force is required. In this regard, the ADE-based variable bias current control strategy is proposed to minimize the energy consumption of the AMB control system without altering the control performance. Experimental results demonstrate the high-accuracy control and significant energy saving performances of the proposed method. The energy improvements compared to baseline were 20.24% and 17.65% for the operation periods of 10 s and 50 s, respectively.