Enantioselective Rhodium-Catalyzed Allylation of Aliphatic Imines: Synthesis of Chiral C Aliphatic Homoallylic Amines

Wei Sian Li, Ting Shen Kuo, Meng Chi Hsieh, Ming Kang Tsai, Ping Yu Wu, Hsyueh Liang Wu*

*此作品的通信作者

研究成果: 雜誌貢獻期刊論文同行評審

6 引文 斯高帕斯(Scopus)

摘要

Reported herein is a method for the efficient syntheses of optically active 1-alkyl homoallylic amines in yields up to 95%, 13.5:1 dr, and 98% ee under mild, aqueous reaction conditions, via the Rh-catalyzed asymmetric allylation of aliphatic aldimines. This method provides a streamlined synthetic platform for the preparation of indolizidine and piperidine alkaloids, thus demonstrating its usefulness.

原文英語
頁(從 - 到)5675-5679
頁數5
期刊Organic Letters
22
發行號14
DOIs
出版狀態已發佈 - 2020 7月 17

ASJC Scopus subject areas

  • 生物化學
  • 物理與理論化學
  • 有機化學

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