Enantioselective organocatalytic Michael Addition of ketones to alkylidene malonates

Siang En Syu, Chan Hui Huang, Ko Wei Chen, Chia Jui Lee, Utpal Das, Yeong Jiunn Jang, Wenwei Lin*

*此作品的通信作者

研究成果: 雜誌貢獻期刊論文同行評審

4 引文 斯高帕斯(Scopus)

摘要

Organocatalysts bearing sulfide or sulfone functions () were studied for the direct asymmetric Michael addition of ketones and alkylidene malonates. The organocatalyst (S)-2-((naphthalen-2-ylthio)methyl)pyrrolidine, bearing a pyrrolidine and a sulfide moiety, showed a very high catalytic activity in the absence of additives. The reaction condition is mild, and the Michael adducts were obtained in very good enantioselectivities (up to 96%), diastereoselectivities (up to >95:5), and chemical yields (up to 95%). Chirality 24:600-605, 2012. © 2012 Wiley Periodicals, Inc.

原文英語
頁(從 - 到)600-605
頁數6
期刊Chirality
24
發行號8
DOIs
出版狀態已發佈 - 2012 八月 1

ASJC Scopus subject areas

  • 分析化學
  • 催化
  • 藥理
  • 藥物發現
  • 光譜
  • 有機化學

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