Enantioselective Aza-Friedel-Crafts Reaction of Heteroarenes with in situ Generated Isoxazolium Ions via Chiral Phosphoric Acid Catalysis

You Song Cheng, Shih Hsien Chan, Gunda Ananda Rao, Ramani Gurubrahamam, Kwunmin Chen*

*此作品的通信作者

研究成果: 雜誌貢獻期刊論文同行評審

摘要

An asymmetric organocatalytic aza-Friedel-Crafts reaction was developed to give the enantioenriched Δ4-isoxazoline scaffold bearing a quaternary-substituted stereogenic centre in good-to-excellent yields and enantioselectivity (50–99%, 55–>99% ee). This protocol involves the in situ generated isoxazolium ions in the presence of a chiral phosphoric acid followed by the heteroarene addition through asymmetric counteranion-directed catalysis. (Figure presented.).

原文英語
頁(從 - 到)3502-3506
頁數5
期刊Advanced Synthesis and Catalysis
363
發行號14
DOIs
出版狀態已發佈 - 2021 七月 20

ASJC Scopus subject areas

  • 催化
  • 有機化學

指紋

深入研究「Enantioselective Aza-Friedel-Crafts Reaction of Heteroarenes with in situ Generated Isoxazolium Ions via Chiral Phosphoric Acid Catalysis」主題。共同形成了獨特的指紋。

引用此