摘要
In this article, the design and synthesis of the chiral camphor derived γ-amino thiol ligand 17 and its application in catalytic enantioselective carbon-carbon forming reactions through the addition of organozinc reagents to carbonyl compounds is described. The catalytic activity and enantioselectivity of ligand 17 is demonstrated in the enantioselective addition of various organozinc reagents to aldehydes and ketoesters, offering the corresponding alcohols in high yields and enantioselectivities. The role of the mercapto group in the highly enantioselective 1,2-addition reaction of organozincs to aldehyde is also discussed.
原文 | 英語 |
---|---|
頁(從 - 到) | 2656-2665 |
頁數 | 10 |
期刊 | Tetrahedron |
卷 | 72 |
發行號 | 21 |
DOIs | |
出版狀態 | 已發佈 - 2016 5月 26 |
ASJC Scopus subject areas
- 生物化學
- 藥物發現
- 有機化學