Enantioselective addition of dialkylzincs to aldehydes catalyzed by (-)-MITH

Ying Ni Cheng, Hsyueh Liang Wu, Ping Yu Wu, Ying Ying Shen, Biing Jiun Uang

研究成果: 雜誌貢獻文章同行評審

13 引文 斯高帕斯(Scopus)

摘要

An effective catalytic system that imparts high enantioselectivity has been disclosed for the synthesis of optically active alcohols, which may undergo further chemical transformations. The enantioselective alkylation of aldehydes with dialkylzincs to afford the corresponding optically active alcohols with excellent enantioselectvities has been achieved in the presence of 0.1-0.5 mol % of the camphor-derived chiral ligand (-)-2-exo-morpholinoisobornane-10-thiol (MITH) (1) at room temperature or at 0 °C. I zinc so too: The enantioselective alkylation of aldehydes with dialkylzincs yielded the desired alcohol products with up to 99 % ee in the presence of 0.1-0.5 mol % of ligand (-)-2-exo-morpholinoisoborne-10-thiol (1) at room temperature or at 0°C.

原文英語
頁(從 - 到)2921-2924
頁數4
期刊Chemistry - An Asian Journal
7
發行號12
DOIs
出版狀態已發佈 - 2012 十二月 1

ASJC Scopus subject areas

  • Biochemistry
  • Organic Chemistry

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