Electron transfer in ruthenium-modified proteins

Morten J. Bjerrum, Danilo R. Casimiro, I. Jy Chang, Angel J. Di Bilio, Harry B. Gray*, Michael G. Hill, Ralf Langen, Gary A. Mines, Lars K. Skov, Jay R. Winkler, Deborah S. Wuttke


研究成果: 雜誌貢獻期刊論文同行評審

117 引文 斯高帕斯(Scopus)


Photochemical techniques have been used to measure the kinetics of intramolecular electron transfer in Ru(bpy)2(im)(His)2+-modified (bpy = 2,2′-bipyridine; im = imidazole) cytochrome c and azurin. A driving-force study with the His33 derivatives of cytochrome c indicates that the reorganization energy (γ) for Fe2+→Ru3+ ET reactions is 0.8 eV. Reductions of the ferriheme by either an excited complex,*Ru2+, or a reduced complex, Ru+, are anomalously fast and may involve formation of an electronically excited ferroheme. The distance dependence of Fe2+→Ru3+ and Cu+→Ru3+ electron transfer in 12 different Ru-modified cytochromes and azurins has been analyzed using a tunneling-pathway model. The ET rates in 10 of the 12 systems exhibit an exponential dependence on metal-metal separation (decay constant of 1.06 å-1) that is consistent with predictions of the pathway model.

頁(從 - 到)295-302
期刊Journal of Bioenergetics and Biomembranes
出版狀態已發佈 - 1995 6月

ASJC Scopus subject areas

  • 生理學
  • 細胞生物學


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