Electron transfer in ruthenium-modified proteins

Morten J. Bjerrum, Danilo R. Casimiro, I. Jy Chang, Angel J. Di Bilio, Harry B. Gray, Michael G. Hill, Ralf Langen, Gary A. Mines, Lars K. Skov, Jay R. Winkler, Deborah S. Wuttke

研究成果: 雜誌貢獻文章

113 引文 斯高帕斯(Scopus)


Photochemical techniques have been used to measure the kinetics of intramolecular electron transfer in Ru(bpy)2(im)(His)2+-modified (bpy = 2,2′-bipyridine; im = imidazole) cytochrome c and azurin. A driving-force study with the His33 derivatives of cytochrome c indicates that the reorganization energy (γ) for Fe2+→Ru3+ ET reactions is 0.8 eV. Reductions of the ferriheme by either an excited complex,*Ru2+, or a reduced complex, Ru+, are anomalously fast and may involve formation of an electronically excited ferroheme. The distance dependence of Fe2+→Ru3+ and Cu+→Ru3+ electron transfer in 12 different Ru-modified cytochromes and azurins has been analyzed using a tunneling-pathway model. The ET rates in 10 of the 12 systems exhibit an exponential dependence on metal-metal separation (decay constant of 1.06 å-1) that is consistent with predictions of the pathway model.

頁(從 - 到)295-302
期刊Journal of Bioenergetics and Biomembranes
出版狀態已發佈 - 1995 六月 1

ASJC Scopus subject areas

  • Physiology
  • Cell Biology

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