Efficient and Enantioselective Rhodium(I)-Catalyzed Arylation of α-Ketoesters: Synthesis of (S)-Flutriafol

Chiung An Chang, Tsung Ying Uang, Jia Hong Jian, Meng Yi Zhou, Ming Liang Chen, Ting Shen Kuo, Ping Yu Wu, Hsyueh Liang Wu

研究成果: 雜誌貢獻文章同行評審

5 引文 斯高帕斯(Scopus)

摘要

An enantioselective addition of arylboronic acids and α-ketoesters promoted by a Rhodium(I)-chiral diene catalyst is reported. The transformation proceeds regioselectively in the presence of as low as 0.5 mol% of the catalyst generated in situ from a Rhodium(I) salt and diene L1, which is a bicyclo[2.2.1] ligand scaffold bearing 2,5 dinaphthyl substituents, to afford tertiary chiral α-hydroxy esters with high stereoselectivities (90–99% ee's) and in 50–>99% yields. The method provides an expeditious and enantioselective synthesis of (S)-flutriafol. (Figure presented.).

原文英語
頁(從 - 到)3381-3390
頁數10
期刊Advanced Synthesis and Catalysis
360
發行號17
DOIs
出版狀態已發佈 - 2018 九月 3

ASJC Scopus subject areas

  • Catalysis
  • Organic Chemistry

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