Effects of caffeic acid and cinnamic acid on glucose uptake in insulin-resistant mouse hepatocytes

D. A.Wei Huang, Szu Chuan Shen, James Swi-Bea Wu*

*此作品的通信作者

研究成果: 雜誌貢獻期刊論文同行評審

77 引文 斯高帕斯(Scopus)

摘要

Tumor necrosis factor-a was used to induce insulin resistance of mouse liver FL83B cells. Two phenolic acids, caffeic acid and cinnamic acid, were then added separately to investigate their effects on glucose uptake of the insulin-resistant cells. The results suggest that these two phenolic acids may promote insulin receptor tyrosyl phosphorylation, up-regulate the expression of insulin signal associated proteins, including insulin receptor, phosphatidylinositol-3 kinase, glycogen synthase, and glucose transporter-2, increase the uptake of glucose, and alleviate insulin resistance in cells as a consequence.

原文英語
頁(從 - 到)7687-7692
頁數6
期刊Journal of Agricultural and Food Chemistry
57
發行號17
DOIs
出版狀態已發佈 - 2009 九月 9

ASJC Scopus subject areas

  • 化學 (全部)
  • 農業與生物科學 (全部)

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