Effects of aprotinin on renal function in chronic hypoxic rats

C. F. Chen*, L. W. Chen, C. T. Chien


研究成果: 雜誌貢獻期刊論文同行評審


The effect of aprotinin, a nonspecific kallikrein inhibitor on renal function was studied in chronic hypoxic rats (high altitude, HA), comparing to control rats kept at sea level (SL). Hypoxia was induced by placing female Wistar rats (195-230 g) in an altitude chamber (5,500 m) 15 hr per day for 4 weeks. Intrarenal arterial administration of aprotinin (300 kiu/kg/min), reduced the urinary kallikrein activity (UKA) in 9 SL and 10 HA anesthetized rats. Aprotinin did not significantly alter the urinary excretion of urine, sodium and potassium in SL rats, however, those parameters increased after aprotinin administration in HA rats. These data support the hypothesis that kallikrein participates in the regulation of renal function in chronic hypoxic rats.

頁(從 - 到)23-26
期刊Chinese Journal of Physiology
出版狀態已發佈 - 1995

ASJC Scopus subject areas

  • 生理學
  • 生理學(醫學)


深入研究「Effects of aprotinin on renal function in chronic hypoxic rats」主題。共同形成了獨特的指紋。