Effects of aprotinin on renal function in chronic hypoxic rats

C. F. Chen, L. W. Chen, Chiang-Ting Chien

研究成果: 雜誌貢獻期刊論文同行評審

摘要

The effect of aprotinin, a nonspecific kallikrein inhibitor on renal function was studied in chronic hypoxic rats (high altitude, HA), comparing to control rats kept at sea level (SL). Hypoxia was induced by placing female Wistar rats (195-230 g) in an altitude chamber (5,500 m) 15 hr per day for 4 weeks. Intrarenal arterial administration of aprotinin (300 kiu/kg/min), reduced the urinary kallikrein activity (UKA) in 9 SL and 10 HA anesthetized rats. Aprotinin did not significantly alter the urinary excretion of urine, sodium and potassium in SL rats, however, those parameters increased after aprotinin administration in HA rats. These data support the hypothesis that kallikrein participates in the regulation of renal function in chronic hypoxic rats.

原文英語
頁(從 - 到)23-26
頁數4
期刊Chinese Journal of Physiology
38
發行號1
出版狀態已發佈 - 1995 一月 1

ASJC Scopus subject areas

  • Physiology
  • Physiology (medical)

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