Dual-Signal Microbial Biosensor for the Detection of Dopamine without Inference from Other Catecholamine Neurotransmitters

Yu Kuan Lin, Yi Chun Yeh

研究成果: 雜誌貢獻文章

13 引文 斯高帕斯(Scopus)

摘要

Dopamine, one of catecholamine neurotransmitters, plays an important role in many brain functions and behavioral responses. In this study, we developed a novel dual-signal whole-cell biosensor for the detection of dopamine through the generation of red fluorescent proteins and 6-decarboxylated betaxanthin pigments. The proposed system responses specifically to dopamine with a detection limit of 1.43 μM. Furthermore, a combination of dual output signals makes it possible to reduce the interference from other catecholamine neurotransmitters, including L-DOPA, epinephrine, and norepinephrine.

原文英語
頁(從 - 到)11178-11182
頁數5
期刊Analytical Chemistry
89
發行號21
DOIs
出版狀態已發佈 - 2017 十一月 7

ASJC Scopus subject areas

  • Analytical Chemistry

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