Dual immobilization and magnetic manipulation of magnetic nanoparticles

S. Y. Yang; Z. F. Jian; H. E. Horng; Chin Yih Hong; H. C. Yang; C. C. Wu; Y. H. Lee

doi:10.1016/j.jmmm.2008.05.048

Dual immobilization and magnetic manipulation of magnetic nanoparticles

S. Y. Yang
, Z. F. Jian
, H. E. Horng
, Chin Yih Hong
, H. C. Yang
, C. C. Wu
, Y. H. Lee

光電工程研究所暨學士學位學程

研究成果: 雜誌貢獻 › 期刊論文 › 同行評審

38 引文斯高帕斯（Scopus）

摘要

By suitably bio-functionalizing the surfaces, magnetic nanoparticles are able to bind specific biomolecules, and may serve as vectors for delivering bio-entities to target tissues. In this work, the synthesis of bio-functionalized magnetic nanoparticles with two kinds of bio-probes is developed. Here, the stem cell is selected as a to-be-delivered bio-entity and infarcted myocardium is the target issue. Thus, cluster designation-34 (CD-34) on stem cell and creatine kinase-MB (CK-MB) (or troponin I) on infarcted myocardium are the specific biomolecules to be bound with bio-functionalized magnetic nanoparticles. In addition to demonstrating the co-coating of two kinds of bio-probes on a magnetic nanoparticle, the feasibility of manipulation on bio-functionalized magnetic nanoparticles by external magnetic fields is investigated.

原文	英語
頁（從 - 到）	2688-2691
頁數	4
期刊	Journal of Magnetism and Magnetic Materials
卷	320
發行號	21
DOIs	https://doi.org/10.1016/j.jmmm.2008.05.048
出版狀態	已發佈 - 2008 11月

ASJC Scopus subject areas

電子、光磁材料
凝聚態物理學

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10.1016/j.jmmm.2008.05.048

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title = "Dual immobilization and magnetic manipulation of magnetic nanoparticles",

abstract = "By suitably bio-functionalizing the surfaces, magnetic nanoparticles are able to bind specific biomolecules, and may serve as vectors for delivering bio-entities to target tissues. In this work, the synthesis of bio-functionalized magnetic nanoparticles with two kinds of bio-probes is developed. Here, the stem cell is selected as a to-be-delivered bio-entity and infarcted myocardium is the target issue. Thus, cluster designation-34 (CD-34) on stem cell and creatine kinase-MB (CK-MB) (or troponin I) on infarcted myocardium are the specific biomolecules to be bound with bio-functionalized magnetic nanoparticles. In addition to demonstrating the co-coating of two kinds of bio-probes on a magnetic nanoparticle, the feasibility of manipulation on bio-functionalized magnetic nanoparticles by external magnetic fields is investigated.",

keywords = "Bio-vector, Magnetic nanoparticles, Stem cell",

author = "Yang, \{S. Y.\} and Jian, \{Z. F.\} and Horng, \{H. E.\} and Hong, \{Chin Yih\} and Yang, \{H. C.\} and Wu, \{C. C.\} and Lee, \{Y. H.\}",

note = "Funding Information: This work is supported by National Science Council, Taiwan under Grant nos., NSC95-2120-M-003-001, 96-2314-B-002-150-MY3, 96-2628-M-003-002, 95-2112-M-003-017-MY2, and 96-2752-M002-016-PAE.",

year = "2008",

month = nov,

doi = "10.1016/j.jmmm.2008.05.048",

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AU - Yang, S. Y.

AU - Jian, Z. F.

AU - Horng, H. E.

AU - Hong, Chin Yih

AU - Yang, H. C.

AU - Wu, C. C.

AU - Lee, Y. H.

N1 - Funding Information: This work is supported by National Science Council, Taiwan under Grant nos., NSC95-2120-M-003-001, 96-2314-B-002-150-MY3, 96-2628-M-003-002, 95-2112-M-003-017-MY2, and 96-2752-M002-016-PAE.

PY - 2008/11

Y1 - 2008/11

N2 - By suitably bio-functionalizing the surfaces, magnetic nanoparticles are able to bind specific biomolecules, and may serve as vectors for delivering bio-entities to target tissues. In this work, the synthesis of bio-functionalized magnetic nanoparticles with two kinds of bio-probes is developed. Here, the stem cell is selected as a to-be-delivered bio-entity and infarcted myocardium is the target issue. Thus, cluster designation-34 (CD-34) on stem cell and creatine kinase-MB (CK-MB) (or troponin I) on infarcted myocardium are the specific biomolecules to be bound with bio-functionalized magnetic nanoparticles. In addition to demonstrating the co-coating of two kinds of bio-probes on a magnetic nanoparticle, the feasibility of manipulation on bio-functionalized magnetic nanoparticles by external magnetic fields is investigated.

AB - By suitably bio-functionalizing the surfaces, magnetic nanoparticles are able to bind specific biomolecules, and may serve as vectors for delivering bio-entities to target tissues. In this work, the synthesis of bio-functionalized magnetic nanoparticles with two kinds of bio-probes is developed. Here, the stem cell is selected as a to-be-delivered bio-entity and infarcted myocardium is the target issue. Thus, cluster designation-34 (CD-34) on stem cell and creatine kinase-MB (CK-MB) (or troponin I) on infarcted myocardium are the specific biomolecules to be bound with bio-functionalized magnetic nanoparticles. In addition to demonstrating the co-coating of two kinds of bio-probes on a magnetic nanoparticle, the feasibility of manipulation on bio-functionalized magnetic nanoparticles by external magnetic fields is investigated.

KW - Bio-vector

KW - Magnetic nanoparticles

KW - Stem cell

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DO - 10.1016/j.jmmm.2008.05.048

M3 - Article

AN - SCOPUS:54249153185

SN - 0304-8853

VL - 320

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EP - 2691

JO - Journal of Magnetism and Magnetic Materials

JF - Journal of Magnetism and Magnetic Materials

IS - 21

ER -

Dual immobilization and magnetic manipulation of magnetic nanoparticles

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