Dual immobilization and magnetic manipulation of magnetic nanoparticles

S. Y. Yang; Z. F. Jian; H. E. Horng; Chin Yih Hong; H. C. Yang; C. C. Wu; Y. H. Lee

doi:10.1016/j.jmmm.2008.05.048

Dual immobilization and magnetic manipulation of magnetic nanoparticles

S. Y. Yang, Z. F. Jian, H. E. Horng, Chin Yih Hong, H. C. Yang, C. C. Wu, Y. H. Lee

光電工程學士學位學程

研究成果: 雜誌貢獻 › 期刊論文 › 同行評審

37 引文斯高帕斯（Scopus）

摘要

By suitably bio-functionalizing the surfaces, magnetic nanoparticles are able to bind specific biomolecules, and may serve as vectors for delivering bio-entities to target tissues. In this work, the synthesis of bio-functionalized magnetic nanoparticles with two kinds of bio-probes is developed. Here, the stem cell is selected as a to-be-delivered bio-entity and infarcted myocardium is the target issue. Thus, cluster designation-34 (CD-34) on stem cell and creatine kinase-MB (CK-MB) (or troponin I) on infarcted myocardium are the specific biomolecules to be bound with bio-functionalized magnetic nanoparticles. In addition to demonstrating the co-coating of two kinds of bio-probes on a magnetic nanoparticle, the feasibility of manipulation on bio-functionalized magnetic nanoparticles by external magnetic fields is investigated.

原文	英語
頁（從 - 到）	2688-2691
頁數	4
期刊	Journal of Magnetism and Magnetic Materials
卷	320
發行號	21
DOIs	https://doi.org/10.1016/j.jmmm.2008.05.048
出版狀態	已發佈 - 2008 11月

ASJC Scopus subject areas

電子、光磁材料
凝聚態物理學

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10.1016/j.jmmm.2008.05.048

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title = "Dual immobilization and magnetic manipulation of magnetic nanoparticles",

abstract = "By suitably bio-functionalizing the surfaces, magnetic nanoparticles are able to bind specific biomolecules, and may serve as vectors for delivering bio-entities to target tissues. In this work, the synthesis of bio-functionalized magnetic nanoparticles with two kinds of bio-probes is developed. Here, the stem cell is selected as a to-be-delivered bio-entity and infarcted myocardium is the target issue. Thus, cluster designation-34 (CD-34) on stem cell and creatine kinase-MB (CK-MB) (or troponin I) on infarcted myocardium are the specific biomolecules to be bound with bio-functionalized magnetic nanoparticles. In addition to demonstrating the co-coating of two kinds of bio-probes on a magnetic nanoparticle, the feasibility of manipulation on bio-functionalized magnetic nanoparticles by external magnetic fields is investigated.",

keywords = "Bio-vector, Magnetic nanoparticles, Stem cell",

author = "Yang, {S. Y.} and Jian, {Z. F.} and Horng, {H. E.} and Hong, {Chin Yih} and Yang, {H. C.} and Wu, {C. C.} and Lee, {Y. H.}",

note = "Funding Information: This work is supported by National Science Council, Taiwan under Grant nos., NSC95-2120-M-003-001, 96-2314-B-002-150-MY3, 96-2628-M-003-002, 95-2112-M-003-017-MY2, and 96-2752-M002-016-PAE.",

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AU - Yang, S. Y.

AU - Jian, Z. F.

AU - Horng, H. E.

AU - Hong, Chin Yih

AU - Yang, H. C.

AU - Wu, C. C.

AU - Lee, Y. H.

N1 - Funding Information: This work is supported by National Science Council, Taiwan under Grant nos., NSC95-2120-M-003-001, 96-2314-B-002-150-MY3, 96-2628-M-003-002, 95-2112-M-003-017-MY2, and 96-2752-M002-016-PAE.

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N2 - By suitably bio-functionalizing the surfaces, magnetic nanoparticles are able to bind specific biomolecules, and may serve as vectors for delivering bio-entities to target tissues. In this work, the synthesis of bio-functionalized magnetic nanoparticles with two kinds of bio-probes is developed. Here, the stem cell is selected as a to-be-delivered bio-entity and infarcted myocardium is the target issue. Thus, cluster designation-34 (CD-34) on stem cell and creatine kinase-MB (CK-MB) (or troponin I) on infarcted myocardium are the specific biomolecules to be bound with bio-functionalized magnetic nanoparticles. In addition to demonstrating the co-coating of two kinds of bio-probes on a magnetic nanoparticle, the feasibility of manipulation on bio-functionalized magnetic nanoparticles by external magnetic fields is investigated.

AB - By suitably bio-functionalizing the surfaces, magnetic nanoparticles are able to bind specific biomolecules, and may serve as vectors for delivering bio-entities to target tissues. In this work, the synthesis of bio-functionalized magnetic nanoparticles with two kinds of bio-probes is developed. Here, the stem cell is selected as a to-be-delivered bio-entity and infarcted myocardium is the target issue. Thus, cluster designation-34 (CD-34) on stem cell and creatine kinase-MB (CK-MB) (or troponin I) on infarcted myocardium are the specific biomolecules to be bound with bio-functionalized magnetic nanoparticles. In addition to demonstrating the co-coating of two kinds of bio-probes on a magnetic nanoparticle, the feasibility of manipulation on bio-functionalized magnetic nanoparticles by external magnetic fields is investigated.

KW - Bio-vector

KW - Magnetic nanoparticles

KW - Stem cell

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Dual immobilization and magnetic manipulation of magnetic nanoparticles

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