Dual immobilization and magnetic manipulation of magnetic nanoparticles

S. Y. Yang, Z. F. Jian, H. E. Horng, Chin Yih Hong, H. C. Yang, C. C. Wu, Y. H. Lee

研究成果: 雜誌貢獻期刊論文同行評審

35 引文 斯高帕斯(Scopus)

摘要

By suitably bio-functionalizing the surfaces, magnetic nanoparticles are able to bind specific biomolecules, and may serve as vectors for delivering bio-entities to target tissues. In this work, the synthesis of bio-functionalized magnetic nanoparticles with two kinds of bio-probes is developed. Here, the stem cell is selected as a to-be-delivered bio-entity and infarcted myocardium is the target issue. Thus, cluster designation-34 (CD-34) on stem cell and creatine kinase-MB (CK-MB) (or troponin I) on infarcted myocardium are the specific biomolecules to be bound with bio-functionalized magnetic nanoparticles. In addition to demonstrating the co-coating of two kinds of bio-probes on a magnetic nanoparticle, the feasibility of manipulation on bio-functionalized magnetic nanoparticles by external magnetic fields is investigated.

原文英語
頁(從 - 到)2688-2691
頁數4
期刊Journal of Magnetism and Magnetic Materials
320
發行號21
DOIs
出版狀態已發佈 - 2008 11月

ASJC Scopus subject areas

  • 電子、光磁材料
  • 凝聚態物理學

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