Doubly end-on azido bridged mixed-valence cobalt trinuclear complex: Spectral study, VTM, inhibitory effect and antimycobacterial activity on human carcinoma and tuberculosis cells

Amitabha Datta; Kuheli Das; Chandana Sen; Nirmal Kumar Karan; Jui Hsien Huang; Chia Her Lin; Eugenio Garribba; Chittaranjan Sinha; Tulin Askun; Pinar Celikboyun; Sandeep B. Mane

doi:10.1016/j.saa.2015.04.014

Doubly end-on azido bridged mixed-valence cobalt trinuclear complex: Spectral study, VTM, inhibitory effect and antimycobacterial activity on human carcinoma and tuberculosis cells

Amitabha Datta^*
, Kuheli Das
, Chandana Sen
, Nirmal Kumar Karan
, Jui Hsien Huang
, Chia Her Lin
, Eugenio Garribba
, Chittaranjan Sinha
, Tulin Askun
, Pinar Celikboyun
, Sandeep B. Mane

^*此作品的通信作者

研究成果: 雜誌貢獻 › 期刊論文 › 同行評審

11 引文斯高帕斯（Scopus）

摘要

Doubly end-on azido-bridged mixed-valence trinuclear cobalt complex, [Co₃(L)₂(N₃)₆(CH₃OH)₂] (1) is afforded by employing a potential monoanionic tetradentate-N₂O₂ Schiff base precursor (2-[[2-(dimethylamino)ethyl]imino}ethyl]-6-methoxyphenol; HL). Single crystal X-ray structure reveals that in 1, the adjacent Co^II and Co^III ions are linked by double end-on azido bridges and thus the full molecule is generated by the site symmetry of a crystallographic twofold rotation axis. Complex 1 is subjected on different spectral analysis such as IR, UV-vis, emission and EPR spectroscopy. On variable temperature magnetic study, we observe that during cooling, the χ_MT values decrease smoothly until 15 K and then reaches to the value 1.56 cm³ K mol^-1 at 2 K. Complex 1 inhibits the cell growth on human lung carcinoma (A549 cells), human colorectal (COLO 205 and HT-29 cells), and human heptacellular (PLC5 cells) carcinoma cells. Complex 1 exhibits anti-mycobacterial activity and considerable efficacy on Mycobacterium tuberculosis H37Rv ATCC 27294 and H37Ra ATCC 25177 strains.

原文	英語
頁（從 - 到）	427-434
頁數	8
期刊	Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy
卷	148
DOIs	https://doi.org/10.1016/j.saa.2015.04.014
出版狀態	已發佈 - 2015 9月 5
對外發佈	是

UN SDG

此研究成果有助於以下永續發展目標

SDG 3 健康與福祉

ASJC Scopus subject areas

分析化學
原子與分子物理與光學
儀器
光譜

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10.1016/j.saa.2015.04.014

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Datta, A., Das, K., Sen, C., Karan, N. K., Huang, J. H., Lin, C. H., Garribba, E., Sinha, C., Askun, T., Celikboyun, P., & Mane, S. B. (2015). Doubly end-on azido bridged mixed-valence cobalt trinuclear complex: Spectral study, VTM, inhibitory effect and antimycobacterial activity on human carcinoma and tuberculosis cells. Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy, 148, 427-434. https://doi.org/10.1016/j.saa.2015.04.014

Doubly end-on azido bridged mixed-valence cobalt trinuclear complex: Spectral study, VTM, inhibitory effect and antimycobacterial activity on human carcinoma and tuberculosis cells. / Datta, Amitabha; Das, Kuheli; Sen, Chandana 等.
於: Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy, 卷 148, 05.09.2015, p. 427-434.

研究成果: 雜誌貢獻 › 期刊論文 › 同行評審

Datta, A, Das, K, Sen, C, Karan, NK, Huang, JH, Lin, CH, Garribba, E, Sinha, C, Askun, T, Celikboyun, P & Mane, SB 2015, 'Doubly end-on azido bridged mixed-valence cobalt trinuclear complex: Spectral study, VTM, inhibitory effect and antimycobacterial activity on human carcinoma and tuberculosis cells', Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy, 卷 148, 頁 427-434. https://doi.org/10.1016/j.saa.2015.04.014

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title = "Doubly end-on azido bridged mixed-valence cobalt trinuclear complex: Spectral study, VTM, inhibitory effect and antimycobacterial activity on human carcinoma and tuberculosis cells",

abstract = "Doubly end-on azido-bridged mixed-valence trinuclear cobalt complex, [Co3(L)2(N3)6(CH3OH)2] (1) is afforded by employing a potential monoanionic tetradentate-N2O2 Schiff base precursor (2-[[2-(dimethylamino)ethyl]imino\}ethyl]-6-methoxyphenol; HL). Single crystal X-ray structure reveals that in 1, the adjacent CoII and CoIII ions are linked by double end-on azido bridges and thus the full molecule is generated by the site symmetry of a crystallographic twofold rotation axis. Complex 1 is subjected on different spectral analysis such as IR, UV-vis, emission and EPR spectroscopy. On variable temperature magnetic study, we observe that during cooling, the χMT values decrease smoothly until 15 K and then reaches to the value 1.56 cm3 K mol-1 at 2 K. Complex 1 inhibits the cell growth on human lung carcinoma (A549 cells), human colorectal (COLO 205 and HT-29 cells), and human heptacellular (PLC5 cells) carcinoma cells. Complex 1 exhibits anti-mycobacterial activity and considerable efficacy on Mycobacterium tuberculosis H37Rv ATCC 27294 and H37Ra ATCC 25177 strains.",

keywords = "Anti-mycobacterial activity, Co complex, Crystal structure, EPR, Inhibitory effect, VTM",

author = "Amitabha Datta and Kuheli Das and Chandana Sen and Karan, \{Nirmal Kumar\} and Huang, \{Jui Hsien\} and Lin, \{Chia Her\} and Eugenio Garribba and Chittaranjan Sinha and Tulin Askun and Pinar Celikboyun and Mane, \{Sandeep B.\}",

year = "2015",

month = sep,

day = "5",

doi = "10.1016/j.saa.2015.04.014",

language = "English",

volume = "148",

pages = "427--434",

journal = "Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy",

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publisher = "Elsevier BV",

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T1 - Doubly end-on azido bridged mixed-valence cobalt trinuclear complex

T2 - Spectral study, VTM, inhibitory effect and antimycobacterial activity on human carcinoma and tuberculosis cells

AU - Datta, Amitabha

AU - Das, Kuheli

AU - Sen, Chandana

AU - Karan, Nirmal Kumar

AU - Huang, Jui Hsien

AU - Lin, Chia Her

AU - Garribba, Eugenio

AU - Sinha, Chittaranjan

AU - Askun, Tulin

AU - Celikboyun, Pinar

AU - Mane, Sandeep B.

PY - 2015/9/5

Y1 - 2015/9/5

N2 - Doubly end-on azido-bridged mixed-valence trinuclear cobalt complex, [Co3(L)2(N3)6(CH3OH)2] (1) is afforded by employing a potential monoanionic tetradentate-N2O2 Schiff base precursor (2-[[2-(dimethylamino)ethyl]imino}ethyl]-6-methoxyphenol; HL). Single crystal X-ray structure reveals that in 1, the adjacent CoII and CoIII ions are linked by double end-on azido bridges and thus the full molecule is generated by the site symmetry of a crystallographic twofold rotation axis. Complex 1 is subjected on different spectral analysis such as IR, UV-vis, emission and EPR spectroscopy. On variable temperature magnetic study, we observe that during cooling, the χMT values decrease smoothly until 15 K and then reaches to the value 1.56 cm3 K mol-1 at 2 K. Complex 1 inhibits the cell growth on human lung carcinoma (A549 cells), human colorectal (COLO 205 and HT-29 cells), and human heptacellular (PLC5 cells) carcinoma cells. Complex 1 exhibits anti-mycobacterial activity and considerable efficacy on Mycobacterium tuberculosis H37Rv ATCC 27294 and H37Ra ATCC 25177 strains.

AB - Doubly end-on azido-bridged mixed-valence trinuclear cobalt complex, [Co3(L)2(N3)6(CH3OH)2] (1) is afforded by employing a potential monoanionic tetradentate-N2O2 Schiff base precursor (2-[[2-(dimethylamino)ethyl]imino}ethyl]-6-methoxyphenol; HL). Single crystal X-ray structure reveals that in 1, the adjacent CoII and CoIII ions are linked by double end-on azido bridges and thus the full molecule is generated by the site symmetry of a crystallographic twofold rotation axis. Complex 1 is subjected on different spectral analysis such as IR, UV-vis, emission and EPR spectroscopy. On variable temperature magnetic study, we observe that during cooling, the χMT values decrease smoothly until 15 K and then reaches to the value 1.56 cm3 K mol-1 at 2 K. Complex 1 inhibits the cell growth on human lung carcinoma (A549 cells), human colorectal (COLO 205 and HT-29 cells), and human heptacellular (PLC5 cells) carcinoma cells. Complex 1 exhibits anti-mycobacterial activity and considerable efficacy on Mycobacterium tuberculosis H37Rv ATCC 27294 and H37Ra ATCC 25177 strains.

KW - Anti-mycobacterial activity

KW - Co complex

KW - Crystal structure

KW - EPR

KW - Inhibitory effect

KW - VTM

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JO - Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy

JF - Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy

ER -

Doubly end-on azido bridged mixed-valence cobalt trinuclear complex: Spectral study, VTM, inhibitory effect and antimycobacterial activity on human carcinoma and tuberculosis cells

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