Dose-response relationships between exercise intensity, cravings, and inhibitory control in methamphetamine dependence: An ERPs study

Dongshi Wang, Chenglin Zhou, Min Zhao, Xueping Wu*, Yu Kai Chang

*此作品的通信作者

研究成果: 雜誌貢獻期刊論文同行評審

87 引文 斯高帕斯(Scopus)

摘要

Background: The present study integrated behavioral and neuroelectric approaches for determining the dose-response relationships between exercise intensity and methamphetamine (MA) craving and between exercise intensity and inhibitory control in individuals with MA dependence. Methods: Ninety-two individuals with MA dependence were randomly assigned to an exercise group (light, moderate, or vigorous intensity) or to a reading control group. The participants then completed a craving self-report at four time points: before exercise, during exercise, immediately after exercise, and 50 min after exercise. Event-related potentials were also recorded while the participants completed a standard Go/NoGo task and an MA-related Go/NoGo task approximately 20 min after exercise cessation. Results: The reduction in self-reported MA craving scores of the moderate and vigorous intensity groups was greater than that of the light intensity and control groups during acute exercise as well as immediately and 50 min following exercise termination. Additionally, an inverted-U-shaped relationship between exercise intensity and inhibitory control was generally observed for the behavioral and neuroelectric indices, with the moderate intensity group exhibiting shorter Go reaction times, increased NoGo accuracy, and larger NoGo-N2 amplitudes. Conclusions: Acute exercise may provide benefits for MA-associated craving and inhibitory control in MA-dependent individuals, as revealed by behavioral and neuroelectric measures. Moderate-intensity exercise may be associated with more positive effects, providing preliminary evidence for the establishment of an exercise prescription regarding intensity for MA dependence.

原文英語
頁(從 - 到)331-339
頁數9
期刊Drug and Alcohol Dependence
161
DOIs
出版狀態已發佈 - 2016 4月 1
對外發佈

ASJC Scopus subject areas

  • 毒理學
  • 藥理
  • 精神病學和心理健康
  • 藥學(醫學)

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