Differential Expression of the c-erbB-2 Gene in Human Small Cell and Non-Small Cell Lung Cancer

Paul M. Schneider, Kang Fang, Jack A. Roth, Mien Chie Hung, Susanna M. Chiocca, Xiaoyan Zhao, John Manning

研究成果: 雜誌貢獻期刊論文同行評審

225 引文 斯高帕斯(Scopus)

摘要

We studied non-small cell lung cancers (NSCLC) from 60 patients for abnormalities in the c-erbB-2 gene. Eleven human lung cancer cell lines, including four derived from small cell lung cancer (SCLC) and seven derived from NSCLC were also examined for altered c-erbB-2 gene expression. Southern blot analysis of paired tumor and normal lung samples demonstrated that amplification of the c-erbB-2 gene is rare in NSCLC (2/60) and not restricted to adenocarcinomas. One patient showed an EcoRI restriction fragment length polymorphism for the cerbB-2 locus. Four of four SCLC cell lines demonstrated minimal or nondetectable expression of c-erbB-2 mRNA compared to high levels of expression by seven of seven NSCLC lines. The highest expression levels were seen in four of four adenocarcinomas. We conclude that c-erbB-2 expression is different in SCLC compared to NSCLC and high expression ofc-erbB-2 is consistently present in lung adenocarcinomas.

原文英語
頁(從 - 到)4968-4971
頁數4
期刊Cancer Research
49
發行號18
出版狀態已發佈 - 1989 九月 15

ASJC Scopus subject areas

  • 腫瘤科
  • 癌症研究

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