Did Acidic Stress Resistance in Vertebrates Evolve as Na+/H+ Exchanger-Mediated Ammonia Excretion in Fish?

Yung Che Tseng, Jia Jiun Yan, Fumiya Furukawa, Pung Pung Hwang*

*此作品的通信作者

研究成果: 雜誌貢獻期刊論文同行評審

3 引文 斯高帕斯(Scopus)

摘要

How vertebrates evolved different traits for acid excretion to maintain body fluid pH homeostasis is largely unknown. The evolution of Na+/H+ exchanger (NHE)-mediated NH4 + excretion in fishes is reported, and the coevolution with increased ammoniagenesis and accompanying gluconeogenesis is speculated to benefit vertebrates in terms of both internal homeostasis and energy metabolism response to acidic stress. The findings provide new insights into our understanding of the possible adaptation of fishes to progressing global environmental acidification. In human kidney, titratable H+ and NH4 + comprise the two main components of net acid excretion. V-type H+-ATPase-mediated H+ excretion may have developed in stenohaline lampreys when they initially invaded freshwater from marine habitats, but this trait is lost in most fishes. Instead, increased reliance on NHE-mediated NH4 + excretion is gradually developed and intensified during fish evolution. Further investigations on more species will be needed to support the hypothesis. Also see the video abstract here https://youtu.be/vZuObtfm-34.

原文英語
文章編號1900161
期刊BioEssays
42
發行號5
DOIs
出版狀態已發佈 - 2020 5月 1
對外發佈

ASJC Scopus subject areas

  • 生物化學、遺傳與分子生物學 (全部)

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