摘要
The diastereoselective cyanation of α-keto amides using trimethylsilyl cyanide in the presence of a Lewis acid is described. The corresponding O-acetylated cyanohydrins are obtained in good to high levels of stereoselectivities. The predominance of products with the S absolute configuration at the newly generated stereogenic center was deduced from single crystal X-ray analysis. 13C NMR data suggest that a preferential s-cis conformation was formed by the chelation of a Lewis acid to the dicarbonyl oxygen atoms.
原文 | 英語 |
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頁(從 - 到) | 448-454 |
頁數 | 7 |
期刊 | Journal of the Chinese Chemical Society |
卷 | 53 |
發行號 | 2 |
DOIs | |
出版狀態 | 已發佈 - 2006 4月 |
ASJC Scopus subject areas
- 一般化學