Diastereoselective conjugate addition of thiols to camphor pyrazolidinone derived chiral α,β-unsaturated carbonyls: Synthesis of β-mercaptocarboxylic acid derivatives

C. H. Lin, K. S. Yang, J. F. Pan, K. Chen

研究成果: 雜誌貢獻文章

33 引文 斯高帕斯(Scopus)

摘要

Reaction of chiral α,β-unsaturated carboxylic acid derivatives 2a-e derived from camphor pyrazolidinone 1 with thiols affords β-mercaptocarboxylic acid derivatives 3a-e with a wide range of stereoselectivities (up to > 90% de). The stereoselectivity as a function of Lewis acid is described. The auxiliary can be easily recovered from the Michael adducts under mild conditions. (C) 2000 Elsevier Science Ltd.

原文英語
頁(從 - 到)6815-6819
頁數5
期刊Tetrahedron Letters
41
發行號35
DOIs
出版狀態已發佈 - 2000 八月 26

    指紋

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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