Diastereoselective Baylis-Hillman reactions: The design and synthesis of a novel camphor-Based chiral auxiliary

Kung Shuo Yang; Kwunmin Chen

doi:10.1021/ol990315n

Diastereoselective Baylis-Hillman reactions: The design and synthesis of a novel camphor-Based chiral auxiliary

Kung Shuo Yang, Kwunmin Chen^*

^*此作品的通信作者

化學系

研究成果: 雜誌貢獻 › 期刊論文 › 同行評審

113 引文斯高帕斯（Scopus）

摘要

Formula presented Reaction of chiral acryloylhydrazide 5 derived from novel auxiliary 4 with aldehydes in the presence of DABCO affords practical levels (up to 98% de) of β-hydroxy-α-methylene carbonyl derivatives, and high optical purity of both diastereomers of 6a-d and 7a-d can be obtained by changing the solvent.

原文	英語
頁（從 - 到）	729-731
頁數	3
期刊	Organic Letters
卷	2
發行號	6
DOIs	https://doi.org/10.1021/ol990315n
出版狀態	已發佈 - 2000 3月 23

ASJC Scopus subject areas

生物化學
物理與理論化學
有機化學

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10.1021/ol990315n

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abstract = "Formula presented Reaction of chiral acryloylhydrazide 5 derived from novel auxiliary 4 with aldehydes in the presence of DABCO affords practical levels (up to 98% de) of β-hydroxy-α-methylene carbonyl derivatives, and high optical purity of both diastereomers of 6a-d and 7a-d can be obtained by changing the solvent.",

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AB - Formula presented Reaction of chiral acryloylhydrazide 5 derived from novel auxiliary 4 with aldehydes in the presence of DABCO affords practical levels (up to 98% de) of β-hydroxy-α-methylene carbonyl derivatives, and high optical purity of both diastereomers of 6a-d and 7a-d can be obtained by changing the solvent.

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Diastereoselective Baylis-Hillman reactions: The design and synthesis of a novel camphor-Based chiral auxiliary

摘要

ASJC Scopus subject areas

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