Diagnosis and prognosis of myocardial infarction on a plasmonic chip

Wei Xu, Lin Wang, Ru Zhang, Xuming Sun, Lin Huang, Haiyang Su, Xunbin Wei, Chia Chun Chen, Jiatao Lou, Hongjie Dai, Kun Qian

    研究成果: 雜誌貢獻期刊論文同行評審

    19 引文 斯高帕斯(Scopus)

    摘要

    Cardiovascular diseases lead to 31.5% of deaths globally, and particularly myocardial infarction (MI) results in 7.4 million deaths per year. Diagnosis of MI and monitoring for prognostic use are critical for clinical management and biomedical research, which require advanced tools with accuracy and speed. Herein, we developed a plasmonic gold nano-island (pGold) chip assay for diagnosis and monitoring of MI. On-chip microarray analysis of serum biomarkers (e.g., cardiac troponin I) afforded up to 130-fold enhancement of near-infrared fluorescence for ultra-sensitive and quantitative detection within controlled periods, using 10 μL of serum only. The pGold chip assay achieved MI diagnostic sensitivity of 100% and specificity of 95.54%, superior to the standard chemiluminescence immunoassay in cardiovascular clinics. Further, we monitored biomarker concentrations regarding percutaneous coronary intervention for prognostic purpose. Our work demonstrated a designed approach using plasmonic materials for enhanced diagnosis and monitoring for prognostic use towards point-of-care testing.

    原文英語
    頁(從 - 到)1654
    頁數1
    期刊Nature Communications
    11
    發行號1
    DOIs
    出版狀態已發佈 - 2020 四月 3

    ASJC Scopus subject areas

    • 化學 (全部)
    • 生物化學、遺傳與分子生物學 (全部)
    • 物理與天文學 (全部)

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