TY - JOUR
T1 - Development of an on-line microextraction method for use in fiber-spray/mass spectrometry
AU - Liou, Yea Wenn
AU - Wang, Jian Siang
AU - Chen, Chien Chung
AU - Lin, Cheng Huang
N1 - Publisher Copyright:
© 2017 Elsevier B.V.
PY - 2017/10
Y1 - 2017/10
N2 - A novel fiber-spray/mass spectrometry method using a piece of a porous hollow fiber is described. An adapter, fabricated by a 3D-printer, was designed to connect the fiber and a standard ESI (electrospray ionization) needle, in which a Taylor cone was formed and the resulting ions were detected by a mass spectrometer. Since a porous hollow fiber is usually used for microextraction, the so-called hollow fiber liquid-phase microextraction (HF-LPME) method, a new methodology that involves coupling HF-LPME and fiber-spray, was developed for the first time. We report herein on the design and testing of a microextraction kit. The kit consists of a centrifuge tube (reservoir for the sample solution) and a piece of a porous hollow fiber (for sample extraction). The kit was placed between the mass inlet and the ESI needle. Using the kit, analytes can be extracted from a very dilute solution and then evaporate and escape from the fiber surface. When they make contact with the ESI plume, which arises from the ESI needle tip, the molecules are ionized and then detected by a mass spectrometer. Using the setup, it was possible to improve the limit of detection after microextraction by ∼360-fold when 3,4-MDMA (3,4-methylenedioxymethamphetamine) was analyzed, and the limit of detection achieved was 2 ng/mL.
AB - A novel fiber-spray/mass spectrometry method using a piece of a porous hollow fiber is described. An adapter, fabricated by a 3D-printer, was designed to connect the fiber and a standard ESI (electrospray ionization) needle, in which a Taylor cone was formed and the resulting ions were detected by a mass spectrometer. Since a porous hollow fiber is usually used for microextraction, the so-called hollow fiber liquid-phase microextraction (HF-LPME) method, a new methodology that involves coupling HF-LPME and fiber-spray, was developed for the first time. We report herein on the design and testing of a microextraction kit. The kit consists of a centrifuge tube (reservoir for the sample solution) and a piece of a porous hollow fiber (for sample extraction). The kit was placed between the mass inlet and the ESI needle. Using the kit, analytes can be extracted from a very dilute solution and then evaporate and escape from the fiber surface. When they make contact with the ESI plume, which arises from the ESI needle tip, the molecules are ionized and then detected by a mass spectrometer. Using the setup, it was possible to improve the limit of detection after microextraction by ∼360-fold when 3,4-MDMA (3,4-methylenedioxymethamphetamine) was analyzed, and the limit of detection achieved was 2 ng/mL.
KW - 3,4-Methylenedioxymethamphetamine
KW - Fiber-spray/mass spectrometry
KW - Hollow fiber liquid phase microextraction
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U2 - 10.1016/j.ijms.2017.07.001
DO - 10.1016/j.ijms.2017.07.001
M3 - Article
AN - SCOPUS:85025830054
SN - 1387-3806
VL - 421
SP - 178
EP - 183
JO - International Journal of Mass Spectrometry
JF - International Journal of Mass Spectrometry
ER -