Development of a normalization algorithm for array comparative genomic hybridization

Sher Singh*, Hung I.Harry Chen, Fang Han Hsu, Mong Hsun Tsai, Eric Y. Chuang, Yidong Chen

*此作品的通信作者

研究成果: 書貢獻/報告類型會議論文篇章

摘要

Genomic instability is one of fundamental factors in tumorigenesis and tumor progression. Many studies have demonstrated that copy-number abnormalities at the DNA level are important in the pathogenesis of cancer. Array Comparative Genomic Hybridization (aCGH), developed based on expression microarray technology, can reveal the chromosomal aberrations in segmental copy at a high-resolution. However, due to the nature of aCGH, many standard expression data processing tools, such as data normalization, often failed to yield satisfactory results. The proposed study demonstrated a novel aCGH normalization procedure, which provides an accurate aCGH data normalization by utilizing the dependency of neighboring probe measurements in aCGH experiments. To facilitate the study, we have developed a Hidden Markov Model (HMM) to simulate a series of aCGH experiment with random DNA copy number alteration. Furthermore, based on this new development, we will establish a user-friendly web system in order to provide convenient aCGH analysis.

原文英語
主出版物標題2006 IEEE International Workshop on Genomic Signal Processing and Statstics, GENSIPS 2006
頁面49-50
頁數2
DOIs
出版狀態已發佈 - 2006 十二月 1
事件2006 IEEE International Workshop on Genomic Signal Processing and Statistics, GENSIPS 2006 - College Station, TX, 美国
持續時間: 2006 五月 282006 五月 30

出版系列

名字2006 IEEE International Workshop on Genomic Signal Processing and Statistics, GENSIPS 2006

其他

其他2006 IEEE International Workshop on Genomic Signal Processing and Statistics, GENSIPS 2006
國家/地區美国
城市College Station, TX
期間2006/05/282006/05/30

ASJC Scopus subject areas

  • 生物化學、遺傳與分子生物學(雜項)
  • 計算機理論與數學
  • 電腦視覺和模式識別
  • 統計與概率

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