摘要
The separation and on-line concentration of lysergic acid diethylamide (LSD) in mouse blood was achieved by means of capillary electrophoresis/fluorescence spectroscopy using sodium dodecyl sulfate (SDS) as the surfactant. Techniques involving on-line sample concentration, including sweeping micellar electrokinetic chromatography (sweeping-MEKC) and cation-selective exhaustive injection-sweep-micellar electrokinetic chromatography (CSEI-sweep-MEKC) were applied; the optimum on-line concentration and separation conditions were determined. In the analysis of an actual sample, LSD was found in a blood sample from a test mouse (0.1 mg LSD fed to a 20 g mouse; ∼1/10 to the value of LD50). As a result, 120 and 30 ng/mL of LSD was detected at 20 and 60 min, respectively, after ingestion of the doses.
原文 | 英語 |
---|---|
頁(從 - 到) | 1031-1037 |
頁數 | 7 |
期刊 | Electrophoresis |
卷 | 24 |
發行號 | 6 |
DOIs | |
出版狀態 | 已發佈 - 2003 3月 |
ASJC Scopus subject areas
- 分析化學
- 生物化學
- 臨床生物化學