Determination of lysergic acid diethylamide (LSD) in mouse blood by capillary electrophoresis/fluorescence spectroscopy with sweeping techniques in micellar electrokinetic chromatography

Ching Fang, Ju Tsung Liu, Shiu Huey Chou, Cheng Huang Lin*

*此作品的通信作者

研究成果: 雜誌貢獻期刊論文同行評審

27 引文 斯高帕斯(Scopus)

摘要

The separation and on-line concentration of lysergic acid diethylamide (LSD) in mouse blood was achieved by means of capillary electrophoresis/fluorescence spectroscopy using sodium dodecyl sulfate (SDS) as the surfactant. Techniques involving on-line sample concentration, including sweeping micellar electrokinetic chromatography (sweeping-MEKC) and cation-selective exhaustive injection-sweep-micellar electrokinetic chromatography (CSEI-sweep-MEKC) were applied; the optimum on-line concentration and separation conditions were determined. In the analysis of an actual sample, LSD was found in a blood sample from a test mouse (0.1 mg LSD fed to a 20 g mouse; ∼1/10 to the value of LD50). As a result, 120 and 30 ng/mL of LSD was detected at 20 and 60 min, respectively, after ingestion of the doses.

原文英語
頁(從 - 到)1031-1037
頁數7
期刊Electrophoresis
24
發行號6
DOIs
出版狀態已發佈 - 2003 三月 1

ASJC Scopus subject areas

  • 分析化學
  • 生物化學
  • 臨床生物化學

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