Determination of Gold Ions in Human Urine Using Genetically Engineered Microorganisms on a Paper Device

Kai Hong Guo, Pei Hsuan Chen, Chieh Lin, Chien Fu Chen, I. Ren Lee, Yi Chun Yeh*

*此作品的通信作者

研究成果: 雜誌貢獻期刊論文同行評審

12 引文 斯高帕斯(Scopus)

摘要

This paper presents a whole-cell biosensor that operates in conjunction with a smartphone-based fluorescence diagnostic system on a paper device to monitor the concentration of gold ions in human urine. The heavy metal-tolerant bacteria Cupriavidus metallidurans was genetically engineered for use as a chassis in a red fluorescent protein (RFP)-based microbial sensor. The biosensor is highly sensitive to gold ions, with a detection limit of 110 nM. The proposed smartphone-based analysis system provides a user-friendly approach to design tools of personal health monitoring for reporting the presence of gold ions in human urine.

原文英語
頁(從 - 到)744-748
頁數5
期刊ACS Sensors
3
發行號4
DOIs
出版狀態已發佈 - 2018 四月 27

ASJC Scopus subject areas

  • 生物工程
  • 儀器
  • 製程化學與技術
  • 流體流動和轉移過程

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