Detection of electrical characteristics of DNA strands immobilized on self-assembled multilayer gold nanoparticles

Chien Ying Tsai; Tien Li Chang; Long Sheng Kuo; Ping Hei Chen

doi:10.1063/1.2390653

Detection of electrical characteristics of DNA strands immobilized on self-assembled multilayer gold nanoparticles

Chien Ying Tsai^*
, Tien Li Chang
, Long Sheng Kuo
, Ping Hei Chen

^*此作品的通信作者

研究成果: 雜誌貢獻 › 期刊論文 › 同行評審

15 引文斯高帕斯（Scopus）

摘要

Electric detection of DNA in biosensors can be achieved by comparing the differences between the electrical characteristics of biosensors with various concentrations of DNA. This study shows significant electrical property differences between single-stranded DNA and double-stranded DNA by immobilizing DNA strands on biosensor's self-assembled multilayer gold nanoparticles. The double-stranded DNA has lower electrical resistance than that of single-stranded DNA. These differences can be possibly utilized for DNA identification.

原文	英語
文章編號	203902
期刊	Applied Physics Letters
卷	89
發行號	20
DOIs	https://doi.org/10.1063/1.2390653
出版狀態	已發佈 - 2006
對外發佈	是

ASJC Scopus subject areas

物理與天文學（雜項）

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10.1063/1.2390653

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abstract = "Electric detection of DNA in biosensors can be achieved by comparing the differences between the electrical characteristics of biosensors with various concentrations of DNA. This study shows significant electrical property differences between single-stranded DNA and double-stranded DNA by immobilizing DNA strands on biosensor's self-assembled multilayer gold nanoparticles. The double-stranded DNA has lower electrical resistance than that of single-stranded DNA. These differences can be possibly utilized for DNA identification.",

author = "Tsai, \{Chien Ying\} and Chang, \{Tien Li\} and Kuo, \{Long Sheng\} and Chen, \{Ping Hei\}",

note = "Funding Information: The authors wish to thank National Nano Device Laboratories under Contract No. NDL-94S-C117 for providing experimental facilities for this research. They also deeply appreciate the financial support of the National Science Council of Taiwan, Republic of China under Contract No. NSC 94-2212-E-002-049.",

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AU - Tsai, Chien Ying

AU - Chang, Tien Li

AU - Kuo, Long Sheng

AU - Chen, Ping Hei

N1 - Funding Information: The authors wish to thank National Nano Device Laboratories under Contract No. NDL-94S-C117 for providing experimental facilities for this research. They also deeply appreciate the financial support of the National Science Council of Taiwan, Republic of China under Contract No. NSC 94-2212-E-002-049.

PY - 2006

Y1 - 2006

N2 - Electric detection of DNA in biosensors can be achieved by comparing the differences between the electrical characteristics of biosensors with various concentrations of DNA. This study shows significant electrical property differences between single-stranded DNA and double-stranded DNA by immobilizing DNA strands on biosensor's self-assembled multilayer gold nanoparticles. The double-stranded DNA has lower electrical resistance than that of single-stranded DNA. These differences can be possibly utilized for DNA identification.

AB - Electric detection of DNA in biosensors can be achieved by comparing the differences between the electrical characteristics of biosensors with various concentrations of DNA. This study shows significant electrical property differences between single-stranded DNA and double-stranded DNA by immobilizing DNA strands on biosensor's self-assembled multilayer gold nanoparticles. The double-stranded DNA has lower electrical resistance than that of single-stranded DNA. These differences can be possibly utilized for DNA identification.

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ER -

Detection of electrical characteristics of DNA strands immobilized on self-assembled multilayer gold nanoparticles

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