@article{1bb2bd819fdb4b5e9b778056c7e7c935,
title = "Design, synthesis, and biological evaluation of novel alkenylthiophenes as potent and selective CB1 cannabinoid receptor antagonists",
abstract = "A novel class of (5-(pent-1-enyl)thiophen-2-yl)pyrazole antagonists was discovered, many of which exhibited potent CB1 activity and good CB1/2 selectivity, suggesting that along with a 1,3-transposition of the carbonyl of the pyrazole 3-carboxamide, bioisosteric replacement of the conventional pyrazole 5-aryl group with a thienyl ring substituted with an appropriate alkenyl moiety is viable.",
author = "Tai, {Chia Liang} and Hung, {Ming Shiu} and Pawar, {Vijay D.} and Tseng, {Shi Liang} and Song, {Jen Shin} and Hsieh, {Wan Ping} and Chiu, {Hua Hao} and Wu, {Hui Chuan} and Hsieh, {Min Tsang} and Kuo, {Chun Wei} and Hsieh, {Chia Chien} and Tsao, {Jing Po} and Chao, {Yu Sheng} and Shia, {Kak Shan}",
year = "2008",
doi = "10.1039/b716434c",
language = "English",
volume = "6",
pages = "447--450",
journal = "Organic and Biomolecular Chemistry",
issn = "1477-0520",
publisher = "Royal Society of Chemistry",
number = "3",
}