Design and construction of paper-spray ionization/mass spectrometry

This chapter discusses general aspects of paper spray ionization that is used in mass spectrometry (MS). The methodology and theory are associated with a number of different related applications. The first part of this chapter discusses the fundamentals of paper spray and some modifications, such as tissue spray, are also included. The second part focuses on recent applications, including the analysis of biologically important molecules. These studies show that paper spray MS has great potential for use as a rapid sampling ionization method and for the direct analysis of biological and chemical samples at ambient conditions.