Copper-Catalyzed Oxidative Cascade Inter-Molecular Double Cyclization of 2-Iodobenzamide Derivatives and Propargyl Dicarbonyl Compounds for Accessing 3-Hydroxy-3-Furylisoindolinone Derivatives

Veerababurao Kavala, Li Chun Lin, Prakash Bhimrao Patil, Chia Chi Fang, Zih Yu Hong, Yi Ru Liou, Yu Nong Chen, Yin Zhi Weng, Sundaramoorthi Sarathkumar, Naidu Sambasiva Rao, Sundaram Suresh, Zongyan Jiang, Ching Fa Yao*

*此作品的通信作者

研究成果: 雜誌貢獻期刊論文同行評審

摘要

A one-pot strategy for the synthesis of 3-hydroxy-3-furylisoindolinone derivatives is reported. The reaction proceeds via a copper-catalyzed oxidative cascade inter-molecular double cyclization of 2-iodobenzamide derivatives and propargyl dicarbonyl compounds in the presence of oxygen. The strategy involves several reactions including cyclization/coupling/double C(sp3)−H functionalization in a cascade manner. A wide range of 2-iodobenzamide substrates containing different substituents as well as various propargyldicarbonyl compounds and propargylsulfonyl aryl ketones can be used to access a variety of 3-hydroxy-3-furylisoindolinone derivatives. (Figure presented.).

原文英語
頁(從 - 到)2801-2814
頁數14
期刊Advanced Synthesis and Catalysis
364
發行號16
DOIs
出版狀態已發佈 - 2022 8月 16

ASJC Scopus subject areas

  • 催化
  • 有機化學

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