摘要
A one-pot strategy for the synthesis of 3-hydroxy-3-furylisoindolinone derivatives is reported. The reaction proceeds via a copper-catalyzed oxidative cascade inter-molecular double cyclization of 2-iodobenzamide derivatives and propargyl dicarbonyl compounds in the presence of oxygen. The strategy involves several reactions including cyclization/coupling/double C(sp3)−H functionalization in a cascade manner. A wide range of 2-iodobenzamide substrates containing different substituents as well as various propargyldicarbonyl compounds and propargylsulfonyl aryl ketones can be used to access a variety of 3-hydroxy-3-furylisoindolinone derivatives. (Figure presented.).
原文 | 英語 |
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頁(從 - 到) | 2801-2814 |
頁數 | 14 |
期刊 | Advanced Synthesis and Catalysis |
卷 | 364 |
發行號 | 16 |
DOIs | |
出版狀態 | 已發佈 - 2022 8月 16 |
ASJC Scopus subject areas
- 催化
- 有機化學
指紋
深入研究「Copper-Catalyzed Oxidative Cascade Inter-Molecular Double Cyclization of 2-Iodobenzamide Derivatives and Propargyl Dicarbonyl Compounds for Accessing 3-Hydroxy-3-Furylisoindolinone Derivatives」主題。共同形成了獨特的指紋。資料集
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CCDC 2145558: Experimental Crystal Structure Determination
Kavala, V. (Contributor), Lin, L.-C. (Contributor), Bhimrao Patil, P. (Contributor), Fang, C.-C. (Contributor), Hong, Z.-Y. (Contributor), Liou, Y.-R. (Contributor), Chen, Y.-N. (Contributor), Weng, Y.-Z. (Contributor), Sarathkumar, S. (Contributor), Sambasiva Rao, N. (Contributor), Suresh, S. (Contributor), Jiang, Z. (Contributor) & Yao, C.-F. (Contributor), Cambridge Crystallographic Data Centre, 2023
DOI: 10.5517/ccdc.csd.cc2b0mkk, http://www.ccdc.cam.ac.uk/services/structure_request?id=doi:10.5517/ccdc.csd.cc2b0mkk&sid=DataCite
資料集: Dataset
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CCDC 2145559: Experimental Crystal Structure Determination
Kavala, V. (Contributor), Lin, L.-C. (Contributor), Bhimrao Patil, P. (Contributor), Fang, C.-C. (Contributor), Hong, Z.-Y. (Contributor), Liou, Y.-R. (Contributor), Chen, Y.-N. (Contributor), Weng, Y.-Z. (Contributor), Sarathkumar, S. (Contributor), Sambasiva Rao, N. (Contributor), Suresh, S. (Contributor), Jiang, Z. (Contributor) & Yao, C.-F. (Contributor), Cambridge Crystallographic Data Centre, 2023
DOI: 10.5517/ccdc.csd.cc2b0mll, http://www.ccdc.cam.ac.uk/services/structure_request?id=doi:10.5517/ccdc.csd.cc2b0mll&sid=DataCite
資料集: Dataset