@article{f99b922d847f4d9bbfe5533d409c7e0e,
title = "Copper-Catalyzed Oxidative Cascade Inter-Molecular Double Cyclization of 2-Iodobenzamide Derivatives and Propargyl Dicarbonyl Compounds for Accessing 3-Hydroxy-3-Furylisoindolinone Derivatives",
abstract = "A one-pot strategy for the synthesis of 3-hydroxy-3-furylisoindolinone derivatives is reported. The reaction proceeds via a copper-catalyzed oxidative cascade inter-molecular double cyclization of 2-iodobenzamide derivatives and propargyl dicarbonyl compounds in the presence of oxygen. The strategy involves several reactions including cyclization/coupling/double C(sp3)−H functionalization in a cascade manner. A wide range of 2-iodobenzamide substrates containing different substituents as well as various propargyldicarbonyl compounds and propargylsulfonyl aryl ketones can be used to access a variety of 3-hydroxy-3-furylisoindolinone derivatives. (Figure presented.).",
keywords = "2-Iodobenzamides, 3-Hydroxy-3-furylisoindolinone, Cascade, Copper, Double cyclization",
author = "Veerababurao Kavala and Lin, {Li Chun} and {Bhimrao Patil}, Prakash and Fang, {Chia Chi} and Hong, {Zih Yu} and Liou, {Yi Ru} and Chen, {Yu Nong} and Weng, {Yin Zhi} and Sundaramoorthi Sarathkumar and {Sambasiva Rao}, Naidu and Sundaram Suresh and Zongyan Jiang and Yao, {Ching Fa}",
note = "Funding Information: We wish to acknowledge the Ministry of Science and Technology ROC (MOST 109-2113-M-003-007-MY2) for financial support for this research. The authors are grateful to the instrumentation center at National Taiwan Normal University for providing analytical data X-ray (Mr. Ting-Shen Kuo), NMR (Ms. Chiu-Hui He), and HRMS (Ms. Hsiu-Min Huan) presented in this paper. Funding Information: . We wish to acknowledge the Ministry of Science and Technology ROC (MOST 109‐2113‐M‐003‐007‐MY2) for financial support for this research. The authors are grateful to the instrumentation center at National Taiwan Normal University for providing analytical data X‐ray (Mr. Ting‐Shen Kuo), NMR (Ms. Chiu‐Hui He), and HRMS (Ms. Hsiu‐Min Huan) presented in this paper Publisher Copyright: {\textcopyright} 2022 Wiley-VCH GmbH.",
year = "2022",
month = aug,
day = "16",
doi = "10.1002/adsc.202200235",
language = "English",
volume = "364",
pages = "2801--2814",
journal = "Advanced Synthesis and Catalysis",
issn = "1615-4150",
publisher = "Wiley-VCH Verlag",
number = "16",
}