Copper-Catalyzed Dual Cyclization for the Synthesis of Quinindolines

Hung Kai Wang, Yu Lun Chio, Gangaram Pallikonda, Hsyueh Liang Wu, Haw Lih Su, Jen Chieh Hsieh

研究成果: 雜誌貢獻期刊論文同行評審

摘要

A synthetic approach to quinindoline derivatives by the Cu-catalyzed dual cyclization has been developed. This catalytic reaction is a practical method for the systematic synthesis of quinindoline core structure, which contains a limited-step synthetic strategy and can tolerant a wide variety of substituents. In addition, the mechanistic study reveals that the reaction initiates from a Lewis acid accelerated addition of aniline to nitrile and provides the indole substructure, and then the subsequent Cu-catalyzed C-N coupling reaction furnishes the quinoline subunit and affords the quinindoline structure.

原文英語
期刊Molecules (Basel, Switzerland)
25
發行號22
DOIs
出版狀態已發佈 - 2020 十一月 13

ASJC Scopus subject areas

  • 分析化學
  • 化學(雜項)
  • 分子醫學
  • 藥學科學
  • 藥物發現
  • 物理與理論化學
  • 有機化學

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