Copper-Catalyzed Cascade Synthesis of 2-Aryl-3-cyanobenzofuran and Dibenzo[ b, f]oxepine-10-carbonitrile Derivatives

Bharath Kumar Villuri, Sachin S. Ichake, Sabbasani Rajasekhara Reddy, Veerababurao Kavala, Vijayalakshmi Bandi, Chun Wei Kuo, Ching Fa Yao

研究成果: 雜誌貢獻文章

4 引文 (Scopus)

摘要

The copper-catalyzed reaction of aryl aldehydes with 2-iodobenzylcyanides afforded 2-aryl-3-cyanobenzofurans in isolated yields of up to 74% in a cascade manner, which involves Knoevenagel condensation, aryl hydroxylation, oxa-Michael addition, and aromatization reactions. Conversely, 2-halo benzaldehydes as reacting partners with 2-iodobenzylcyanide regioselectively furnished dibenzo[b,f]oxepine-10-carbonitrile derivatives up to 85% isolated yields via tandem Knoevenagel condensation, aryl hydroxylation, and Ullmann coupling reactions.

原文英語
頁(從 - 到)10241-10247
頁數7
期刊Journal of Organic Chemistry
83
發行號17
DOIs
出版狀態已發佈 - 2018 九月 7

指紋

Oxepins
Hydroxylation
Copper
Condensation
Benzaldehydes
Derivatives
Aromatization
Aldehydes

ASJC Scopus subject areas

  • Organic Chemistry

引用此文

Copper-Catalyzed Cascade Synthesis of 2-Aryl-3-cyanobenzofuran and Dibenzo[ b, f]oxepine-10-carbonitrile Derivatives. / Villuri, Bharath Kumar; Ichake, Sachin S.; Reddy, Sabbasani Rajasekhara; Kavala, Veerababurao; Bandi, Vijayalakshmi; Kuo, Chun Wei; Yao, Ching Fa.

於: Journal of Organic Chemistry, 卷 83, 編號 17, 07.09.2018, p. 10241-10247.

研究成果: 雜誌貢獻文章

Villuri, Bharath Kumar ; Ichake, Sachin S. ; Reddy, Sabbasani Rajasekhara ; Kavala, Veerababurao ; Bandi, Vijayalakshmi ; Kuo, Chun Wei ; Yao, Ching Fa. / Copper-Catalyzed Cascade Synthesis of 2-Aryl-3-cyanobenzofuran and Dibenzo[ b, f]oxepine-10-carbonitrile Derivatives. 於: Journal of Organic Chemistry. 2018 ; 卷 83, 編號 17. 頁 10241-10247.
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abstract = "The copper-catalyzed reaction of aryl aldehydes with 2-iodobenzylcyanides afforded 2-aryl-3-cyanobenzofurans in isolated yields of up to 74{\%} in a cascade manner, which involves Knoevenagel condensation, aryl hydroxylation, oxa-Michael addition, and aromatization reactions. Conversely, 2-halo benzaldehydes as reacting partners with 2-iodobenzylcyanide regioselectively furnished dibenzo[b,f]oxepine-10-carbonitrile derivatives up to 85{\%} isolated yields via tandem Knoevenagel condensation, aryl hydroxylation, and Ullmann coupling reactions.",
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AU - Kavala, Veerababurao

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