Contribution of creatine to protein homeostasis in athletes after endurance and sprint running

Fu Chun Tang, Chun Chen Chan, Po Ling Kuo

研究成果: 雜誌貢獻文章

11 引文 (Scopus)

摘要

Purpose: Few studies have focused on the metabolic changes induced by creatine supplementation. This study investigated the effects of creatine supplementation on plasma and urinary metabolite changes of athletes after endurance and sprint running. Methods: Twelve male athletes (20.3 ± 1.4 y) performed two identical (65-70 % maximum heart rate reserved) 60 min running exercises (endurance trial) before and after creatine supplementation (12 g creatine monohydrate/day for 15 days), followed by a 5-day washout period. Subsequently, they performed two identical 100 m sprint running exercises (power trial) before and after 15 days of creatine supplementation in accordance with the supplementary protocol of the endurance trial. Body composition measurements were performed during the entire study. Plasma samples were examined for the concentrations of glucose, lactate, branched-chain amino acids (BCAAs), free-tryptophan (f-TRP), glutamine, alanine, hypoxanthine, and uric acid. Urinary samples were examined for the concentrations of hydroxyproline, 3-methylhistidine, urea nitrogen, and creatinine. Results: Creatine supplementation significantly increased body weights of the athletes of endurance trial. Plasma lactate concentration and ratio of f-TRP/BCAAs after recovery from endurance running were significantly decreased with creatine supplementation. Plasma purine metabolites (the sum of hypoxanthine and uric acid), glutamine, urinary 3-methylhistidine, and urea nitrogen concentrations tended to decrease before running in trials with creatine supplements. After running, urinary hydroxyproline concentration significantly increased in the power trial with creatine supplements. Conclusions: The findings suggest that creatine supplementation tended to decrease muscle glycogen and protein degradation, especially after endurance exercise. However, creatine supplementation might induce collagen proteolysis in athletes after sprint running.

原文英語
頁(從 - 到)61-71
頁數11
期刊European Journal of Nutrition
53
發行號1
DOIs
出版狀態已發佈 - 2014 二月 1

指紋

Creatine
Running
Athletes
Homeostasis
Proteins
Branched Chain Amino Acids
Hypoxanthine
Hydroxyproline
Exercise
Uric Acid
Glutamine
Tryptophan
Proteolysis
Urea
Lactic Acid
Nitrogen
Muscle Proteins
Clinical Protocols
Body Composition
Glycogen

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

引用此文

Contribution of creatine to protein homeostasis in athletes after endurance and sprint running. / Tang, Fu Chun; Chan, Chun Chen; Kuo, Po Ling.

於: European Journal of Nutrition, 卷 53, 編號 1, 01.02.2014, p. 61-71.

研究成果: 雜誌貢獻文章

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abstract = "Purpose: Few studies have focused on the metabolic changes induced by creatine supplementation. This study investigated the effects of creatine supplementation on plasma and urinary metabolite changes of athletes after endurance and sprint running. Methods: Twelve male athletes (20.3 ± 1.4 y) performed two identical (65-70 {\%} maximum heart rate reserved) 60 min running exercises (endurance trial) before and after creatine supplementation (12 g creatine monohydrate/day for 15 days), followed by a 5-day washout period. Subsequently, they performed two identical 100 m sprint running exercises (power trial) before and after 15 days of creatine supplementation in accordance with the supplementary protocol of the endurance trial. Body composition measurements were performed during the entire study. Plasma samples were examined for the concentrations of glucose, lactate, branched-chain amino acids (BCAAs), free-tryptophan (f-TRP), glutamine, alanine, hypoxanthine, and uric acid. Urinary samples were examined for the concentrations of hydroxyproline, 3-methylhistidine, urea nitrogen, and creatinine. Results: Creatine supplementation significantly increased body weights of the athletes of endurance trial. Plasma lactate concentration and ratio of f-TRP/BCAAs after recovery from endurance running were significantly decreased with creatine supplementation. Plasma purine metabolites (the sum of hypoxanthine and uric acid), glutamine, urinary 3-methylhistidine, and urea nitrogen concentrations tended to decrease before running in trials with creatine supplements. After running, urinary hydroxyproline concentration significantly increased in the power trial with creatine supplements. Conclusions: The findings suggest that creatine supplementation tended to decrease muscle glycogen and protein degradation, especially after endurance exercise. However, creatine supplementation might induce collagen proteolysis in athletes after sprint running.",
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