Clove extract and eugenol suppress inflammatory responses elicited by Propionibacterium acnes in vitro and in vivo

Tsung Hsien Tsai, Wen Cheng Huang, Tsung Jung Lien, Yu Han Huang, Hsiang Chang, Chun Hsien Yu*, Po Jung Tsai

*此作品的通信作者

研究成果: 雜誌貢獻期刊論文同行評審

7 引文 斯高帕斯(Scopus)

摘要

Acne vulgaris is a multifactorial inflammatory disease involving an activation of the immune response to Propionibacterium acnes. The aim of this study is to determine the effects of clove (Syzygium aromaticum L.) extract and eugenol against P. acnes-induced inflammatory responses. The results showed that treatments of ethanolic clove extract (ECE) or eugenol at noncytotoxic concentrations significantly suppressed P. acnes-stimulated NF-κB-mediated tumor necrosis factor-α, interleukin (IL)-1β, and IL-8 productions and matrix metalloproteinase-9 expression in THP-1 cells in vitro. In order to investigate their effects in vivo, histological assessment was examined in the P. acnes-induced mouse ear edema model. The concomitant intradermal injection of ECE and eugenol resulted in reduction of ear swelling in mice along with microabscess. These observations demonstrate that ECE and eugenol inhibit P. acnes-induced inflammatory responses and suggest that ECE and eugenol might be a beneficial agent in treatment of skin inflammation induced by P. acnes.

原文英語
頁(從 - 到)916-931
頁數16
期刊Food and Agricultural Immunology
28
發行號5
DOIs
出版狀態已發佈 - 2017 九月 3

ASJC Scopus subject areas

  • 食品科學
  • 免疫學
  • 農學與作物科學

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