Chiral separation of 3,4-methylenedioxymeth-amphetamine and related compounds in clandestine tablets and urine samples by capillary electrophoresis/fluorescence spectroscopy

Yu San Huang, Ju Tsung Liu, Li Chang Lin, Cheng-Huang Lin*

*此作品的通信作者

研究成果: 雜誌貢獻期刊論文同行評審

22 引文 斯高帕斯(Scopus)

摘要

The R-(-)- and S-(+)-isomers of 3,4-methylenedioxymethamphetamine (MDMA) and its metabolite 3,4-methylenedioxyamphetamine (MDA) were prepared, identified by gas chromatography/mass spectrometry (GC/MS) and then used as standards in a series of capillary electrophoresis (CE) experiments. Using these R-(-)- and S-(+)- isomers, the distribution of (RS)-MDA and (RS)-MDMA stereoisomers in clandestine tablets and suspect urine samples were identified. Several electrophoretic parameters, such as the concentration of β-cyclodextrin used in the electrophoretic separation and the amount of organic solvents required for the separation, were optimized.

原文英語
頁(從 - 到)1097-1104
頁數8
期刊Electrophoresis
24
發行號6
DOIs
出版狀態已發佈 - 2003 三月

ASJC Scopus subject areas

  • 分析化學
  • 生物化學
  • 臨床生物化學

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