Chinese Herbal Medicine Formula Guizhi Li-Zhong Tang as an Alternative to Antibiotic Feed Additives for Preventing Pneumonia in Piglets through Antioxidant, Anti-Inflammatory, and Antiapoptotic Protection

Che Hsuan Wang, Wan Jhen Wu, Li Yu Su, Chen Wen Lu, Pei Hwa Wang, Ming Chung Lee, Wu Chang Chuang, Sheue Er Wang, Chung Hsin Wu*

*此作品的通信作者

研究成果: 雜誌貢獻期刊論文同行評審

摘要

Weanling piglets often develop respiratory diseases such as pneumonia because they encounter substantial environmental stress. This study investigated an alternative herbal feed additive, Guizhi Li-Zhong Tang (GLZ), for preventing pneumonia in weanling piglets. An in vitro experiment demonstrated that GLZ has high antioxidant capacity and low cytotoxicity toward Kupffer cells. In addition, GLZ treatment can alleviate lipopolysaccharide (LPS)-induced damage in Kupffer cells. A total of 94 4-week-old piglets were randomly divided into three groups, which received sham treatment, 0.2% Tilmicosin antibiotic (TAB) treatment, or 0.2% GLZ treatment. Piglets receiving the GLZ treatment had a higher survival rate and higher immunoglobulin G levels but lower allergy-related eosinophil levels and cough incidence than did piglets receiving the sham or 0.2% TAB treatments. Through immunohistochemistry and Western blot analysis, we discovered that piglets receiving the 0.2% GLZ treatment had significantly higher expression of antioxidant-related SOD2 and lower expression of oxidative-stress-related 3-NT (p<0.01), inflammation-related TNF-α (p<0.01) and NF-B (p<0.05), and apoptosis-related caspase-3 (p<0.01) in lung tissue than did piglets receiving the sham or 0.2% TAB treatment. Therefore, GLZ treatment is promising as an alternative to antibiotic medicine for weanling piglets because of its protective antioxidative, anti-inflammatory, and antiapoptotic effects in lung tissue.

原文英語
文章編號4978783
期刊Evidence-based Complementary and Alternative Medicine
2021
DOIs
出版狀態已發佈 - 2021

ASJC Scopus subject areas

  • 補充和替代醫學

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